IGF1

Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review.
[19956424] Am J Transl Res 1(2): 101-14 (2009)

Treatment of dwarfism with recombinant human insulin-like growth factor-1.
[19946434] Dtsch Arztebl Int 106(43): 703-9 (2009)

Myostatin, the cardiac chalone of insulin-like growth factor-1.
[16226233] Cardiovasc Res 68(3): 347-9 (2005)

The insulin-like growth factor system and its receptors: A potential novel anticancer target.
[19707463] Biologics 2(4): 855-64 (2008)

Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency.
[19707272] Ther Clin Risk Manag 5(3): 553-9 (2009)

Nutritional regulation of somatomedin.
[373416] Am J Clin Nutr 32(5): 1082-96 (1979)

Inhibition of colon cancer cell growth by dietary components: role of the insulin-like growth factor (IGF) system.
[18296350] Asia Pac J Clin Nutr 17 Suppl 1(-): 257-60 (2008)

Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.
[12795426] Recent Prog Horm Res 58(-): 325-42 (2003)

An overview of currently available anti-insulin-like growth factor I receptor antibodies.
[20103882] Biosci Trends 1(3): 128-33 (2007)

IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.
[12545204] Acta Biochim Pol 49(4): 979-90 (2002)

Differential regulation of signaling pathways for insulin and insulin-like growth factor I.
[10453981] Acta Biochim Pol 46(1): 51-60 (1999)

Targeting insulin-like growth factor type 1 receptor in cancer therapy.
[19876700] Target Oncol 4(4): 255-66 (2009)

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.
[18790742] Mol Cancer Ther 7(9): 2575-88 (2008)

Disrupting insulin-like growth factor signaling as a potential cancer therapy.
[17237261] Mol Cancer Ther 6(1): 1-12 (2007)

The insulin-like growth factor system as a therapeutic target in colorectal cancer.
[11996463] Ann Oncol 13(3): 349-56 (2002)

Targeting insulin-like growth factor pathways.
[16450000] Br J Cancer 94(4): 465-8 (2006)

Insulin-like growth factors and cancer.
[1313689] Br J Cancer 65(3): 311-20 (1992)

Role of insulin-like growth factor 1 receptor signalling in cancer.
[15956962] Br J Cancer 92(12): 2097-101 (2005)

The type 1 insulin-like growth factor receptor pathway.
[18927274] Clin Cancer Res 14(20): 6364-70 (2008)

IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor.
[17875788] Clin Cancer Res 13(18 Pt 2): 5549s-5555s (2007)

Insulin-like growth factor-I axis as a pathway for cancer chemoprevention.
[17020962] Clin Cancer Res 12(19): 5611-4 (2006)

Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer.
[12096082] J Natl Cancer Inst 94(13): 972-80 (2002)

Role of the insulin-like growth factor family in cancer development and progression.
[10995803] J Natl Cancer Inst 92(18): 1472-89 (2000)

The role of IGF-1R in pediatric malignancies.
[19126579] Oncologist 14(1): 83-91 (2009)

The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer.
[18245009] Oncologist 13(1): 16-24 (2008)

Type I insulin-like growth factor receptor as a therapeutic target in cancer.
[16287993] Cancer Res 65(22): 10123-7 (2005)

The contradictions of the insulin-like growth factor 1 receptor.
[11114737] Oncogene 19(49): 5574-81 (2000)

The role of the IGF system in cancer growth and metastasis: overview and recent insights.
[16931767] Endocr Rev 28(1): 20-47 (2007)

The insulin-like growth factor system and its pleiotropic functions in brain.
[16131630] Endocr Rev 26(7): 916-43 (2005)

Cellular actions of the insulin-like growth factor binding proteins.
[12466191] Endocr Rev 23(6): 824-54 (2002)

The effects of insulin-like growth factors on tumorigenesis and neoplastic growth.
[10857553] Endocr Rev 21(3): 215-44 (2000)

The insulin-like growth factor-binding protein (IGFBP) superfamily.
[10605625] Endocr Rev 20(6): 761-87 (1999)

Insulin-like growth factor-I resistance.
[9793761] Endocr Rev 19(5): 625-46 (1998)

Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.
[9408744] Endocr Rev 18(6): 801-31 (1997)

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.
[10744620] FASEB J 14(5): 629-40 (2000)

Insulin-like growth factors I and II.
[2197088] Eur J Biochem 190(3): 445-62 (1990)

The role of insulin-like growth factor 2 and its receptors in human tumors.
[12606812] Mol Med 8(12): 771-80 (2002)

Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans.
[18713961] Am J Physiol Endocrinol Metab 295(5): E991-9 (2008)

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.
[14534077] Am J Physiol Endocrinol Metab 285(5): E1064-71 (2003)

Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.
[10826997] Am J Physiol Endocrinol Metab 278(6): E967-76 (2000)

Clinical uses of insulin-like growth factor I.
[8116999] Ann Intern Med 120(7): 593-601 (1994)

IGF1R signalling and its inhibition.
[17259557] Endocr Relat Cancer 13 Suppl 1(-): S33-43 (2006)

Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions.
[14713267] Endocr Relat Cancer 10(4): 561-78 (2003)

Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells.
[12790794] Endocr Relat Cancer 10(2): 331-45 (2003)

The IGF system and breast cancer.
[11566611] Endocr Relat Cancer 8(3): 197-209 (2001)

Insights from insulin-like growth factor binding protein transgenic mice.
[12239079] Endocrinology 143(10): 3711-4 (2002)

Genetic disorders in the GH IGF-I axis in mouse and man.
[17785692] Eur J Endocrinol 157 Suppl 1(-): S15-26 (2007)

Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer.
[16299029] Gut 55(5): 689-94 (2006)

The somatomedin hypothesis 2007: 50 years later.
[17986643] J Clin Endocrinol Metab 92(12): 4529-35 (2007)

Insulin-like growth factors in pediatric health and disease.
[10599688] J Clin Endocrinol Metab 84(12): 4355-61 (1999)

Insulin-like growth factors and skeletal growth: possibilities for therapeutic interventions.
[10599687] J Clin Endocrinol Metab 84(12): 4349-54 (1999)

The binding protein's binding protein--clinical applications of acid-labile subunit (ALS) measurement.
[9398692] J Clin Endocrinol Metab 82(12): 3941-3 (1997)

Specifying the cellular responses to IGF signals: roles of IGF-binding proteins.
[12379489] J Endocrinol 175(1): 41-54 (2002)

IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms.
[12379487] J Endocrinol 175(1): 19-31 (2002)

Comparative endocrinology of the insulin-like growth factor-binding protein.
[12379486] J Endocrinol 175(1): 3-18 (2002)

The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system.
[11431138] J Endocrinol 170(1): 63-70 (2001)

Insulin-like growth factor-binding proteins: functional diversity or redundancy?
[9801453] J Mol Endocrinol 21(2): 97-107 (1998)

The three dimensional structure of the type I insulin-like growth factor receptor.
[11376122] Mol Pathol 54(3): 125-32 (2001)

Insulin growth factor I and hypogonadism in cirrhosis.
[10706573] Hepatology 31(3): 783-4 (2000)

Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor (review).
[9852311] Int J Mol Med 1(5): 883-8 (1998)

Mechanisms by which IGF-I may promote cancer.
[14688466] Cancer Biol Ther 2(6): 630-5 (2003)

The multi-functional role of insulin-like growth factor binding proteins in bone.
[15549410] Pediatr Nephrol 20(3): 261-8 (2005)

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.
[20098959] ScientificWorldJournal 10(-): 161-77 (2010)

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
[21115525] Philos Trans R Soc Lond B Biol Sci 366(1561): 9-16 (2011)

Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium.
[20591980] J Clin Endocrinol Metab 95(9): 4184-91 (2010)

Off-label use of recombinant igf-I to promote growth: is it appropriate?
[20133470] J Clin Endocrinol Metab 95(2): 505-8 (2010)

New molecular mechanisms of GH resistance.
[15339238] Eur J Endocrinol 151 Suppl 1(-): S11-5 (2004)

Central effects of the somatotropic system.
[14585082] Eur J Endocrinol 149(5): 377-92 (2003)

Idiopathic short stature: will genetics influence the choice between GH and IGF-I therapy?
[17785695] Eur J Endocrinol 157 Suppl 1(-): S33-7 (2007)

IGF-I treatment of insulin resistance.
[17785698] Eur J Endocrinol 157 Suppl 1(-): S51-6 (2007)

IGF-I therapy in growth disorders.
[17785699] Eur J Endocrinol 157 Suppl 1(-): S57-60 (2007)

Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.
[19075184] Endocr Rev 30(1): 51-74 (2009)

Unraveling insulin-like growth factor binding protein-3 actions in human disease.
[19477944] Endocr Rev 30(5): 417-37 (2009)

The role of liver-derived insulin-like growth factor-I.
[19589948] Endocr Rev 30(5): 494-535 (2009)

The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth.
[20921199] J Physiol 589(Pt 1): 7-20 (2011)

State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors.
[21356169] Discov Med 11(57): 144-53 (2011)

IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions.
[19438508] Br J Pharmacol 157(6): 881-91 (2009)

Biological & physiological aspects of action of insulin-like growth factor peptide family.
[17598937] Indian J Med Res 125(4): 511-22 (2007)

Insulin like growth factors and growth hormone deficiency.
[17536135] Indian Pediatr 44(5): 349-53 (2007)

CSF-1, IGF-1, and the control of postnatal growth and development.
[20519640] J Leukoc Biol 88(3): 475-81 (2010)

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
[20399660] Trends Cell Biol 20(7): 427-34 (2010)

Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systems.
[20032049] Endocrinology 151(4): 1403-8 (2010)

Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.
[20130113] Endocrinology 151(3): 865-75 (2010)

The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.
[20631046] J Endocrinol 206(3): 249-59 (2010)

Maternal growth factor regulation of human placental development and fetal growth.
[20817666] J Endocrinol 207(1): 1-16 (2010)

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
[19180501] Arthritis Rheum 60(2): 492-500 (2009)

The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.
[18801901] Endocrinology 150(1): 277-85 (2009)

Basic and clinical significance of IGF-I-induced signatures in cancer.
[20051101] BMC Med 8(-): 2 (2010)

The proliferating role of insulin and insulin-like growth factors in cancer.
[20663687] Trends Endocrinol Metab 21(10): 610-8 (2010)

IGF-1, oxidative stress and atheroprotection.
[20071192] Trends Endocrinol Metab 21(4): 245-54 (2010)

Defining the pathway to insulin-like growth factor system targeting in cancer.
[20599789] Biochem Pharmacol 80(8): 1115-24 (2010)

From broken to old: DNA damage, IGF1 endocrine suppression and aging.
[17481965] DNA Repair (Amst) 6(9): 1386-90 (2007)

Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies.
[19491931] Eur J Hum Genet 17(12): 1668-75 (2009)

Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
[20392809] Pharmacol Rev 62(2): 199-236 (2010)

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.
[20975071] J Clin Oncol 28(33): 4985-95 (2010)

Targeting insulin-like growth factor axis in hepatocellular carcinoma.
[21729319] J Hematol Oncol 4(-): 30 (2011)

IGF-1 receptor inhibitors in clinical trials--early lessons.
[19023648] J Mammary Gland Biol Neoplasia 13(4): 471-83 (2008)

Running on empty: how p53 controls INS/IGF signaling and affects life span.
[18598747] Exp Gerontol 44(1-2): 93-100 (2009)

The insulin-like growth factor system.
[14668044] Exp Diabesity Res 4(4): 205-12 (2003)

The role of the insulin-like growth factors and their binding proteins in glucose homeostasis.
[14668045] Exp Diabesity Res 4(4): 213-24 (2003)

Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy.
[17011663] Diabetes Res Clin Pract 76(2): 177-86 (2007)

The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.
[17826224] Growth Horm IGF Res 18(1): 17-25 (2008)

Insulin-like growth factor I and the pathogenesis of delirium: a review of current evidence.
[21766035] J Aging Res 2011(-): 951403 (2011)

Downregulation of serum IGF-1 for treatment of early worsening of diabetic retinopathy: a long-term follow-up of two cases.
[19940532] Ophthalmologica 224(4): 243-6 (2010)

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.
[21798082] Skelet Muscle 1(1): 4 (2011)

The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency.
[18359741] Hormones (Athens) 7(1): 24-7 (2008)

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs.
[15528274] Mol Endocrinol 19(1): 1-11 (2005)

The link between the metabolic syndrome and cancer.
[21912508] Int J Biol Sci 7(7): 1003-15 (2011)

GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.
[20197666] Horm Res Paediatr 73(3): 153-60 (2010)

Genetic disorders in the growth hormone - insulin-like growth factor-I axis.
[16917171] Horm Res 66(5): 221-30 (2006)

Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology.
[18325486] Cell Immunol 252(1-2): 91-110 (2008)

Targeting insulin-like growth factor signaling: rational combination strategies.
[20807783] Mol Cancer Ther 9(9): 2447-9 (2010)

A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.
[21154998] World J Gastroenterol 16(46): 5779-89 (2010)

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