Interleukin24 MDA7

Is mda-7/IL-24 a "magic bullet" for cancer?
[16287994] Cancer Res 65(22): 10128-38 (2005)

Interleukin-24 and its receptors.
[15667561] Immunology 114(2): 166-70 (2005)

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).
[17912425] Int J Oncol 31(5): 985-1007 (2007)

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.
[20613485] Anticancer Drugs 21(8): 725-31 (2010)

mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.
[14508078] Cancer Biol Ther 2(4 Suppl 1): S23-37 (2003)

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.
[19276652] Cancer Biol Ther 8(5): 391-400 (2009)

mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.
[16464504] Pharmacol Ther 111(3): 596-628 (2006)

Structural analysis of cytokines comprising the IL-10 family.
[20846897] Cytokine Growth Factor Rev 21(5): 325-30 (2010)

mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
[20926331] Cytokine Growth Factor Rev 21(5): 381-91 (2010)

[A mini-review of targeting gene-virotherapy of cancer].
[17059786] Ai Zheng 25(10): 1320-2 (2006)

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24).
[21610321] Autophagy 7(9): 1076-7 (2011)

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
[18299661] Autophagy 4(4): 513-5 (2008)

Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
[19965640] Blood 115(9): 1718-26 (2010)

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.
[20137089] BMC Cancer 10(): 34 (2010)

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer.
[20737563] Cancer 116(24): 5637-49 (2010)

Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery.
[20948318] Cancer Biol Ther 10(12): 1290-305 (2011)

The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus.
[20574150] Cancer Biol Ther 10(3): 242-50 (2010)

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.
[20234182] Cancer Biol Ther 9(7): 537-8 (2010)

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins.
[20107314] Cancer Biol Ther 9(7): 526-36 (2010)

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
[18376144] Cancer Biol Ther 7(6): 917-33 (2008)

Potential use of MDA-7 as a biological adjuvant for radiation therapy.
[15326389] Cancer Biol Ther 3(8): 752-4 (2004)

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
[15197348] Cancer Biol Ther 3(8): 739-51 (2004)

mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
[14508103] Cancer Biol Ther 2(4): 347-53 (2003)

Tumour suppressor function of MDA-7/IL-24 in human breast cancer.
[20735832] Cancer Cell Int 10(): 29 (2010)

Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.
[20523363] Cancer Gene Ther 17(9): 664-74 (2010)

Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
[20406981] Cancer Res 70(9): 3667-76 (2010)

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.
[20501829] Cancer Res 70(12): 5034-45 (2010)

Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.
[18768668] Cancer Res 68(18): 7439-47 (2008)

Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24.
[18483274] Cancer Res 68(10): 3890-8 (2008)

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.
[17545625] Cancer Res 67(11): 5434-42 (2007)

Molecular target-based therapy of pancreatic cancer.
[16489047] Cancer Res 66(4): 2403-13 (2006)

A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells.
[17178890] Cancer Res 66(24): 11922-31 (2006)

BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis.
[16912197] Cancer Res 66(16): 8182-91 (2006)

Activation of the Fas-FasL signaling pathway by MDA-7/IL-24 kills human ovarian cancer cells.
[15833826] Cancer Res 65(8): 3017-24 (2005)

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.
[15126330] Cancer Res 64(9): 2988-93 (2004)

Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.
[14678967] Cancer Res 63(23): 8138-44 (2003)

Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.
[12941841] Cancer Res 63(16): 5105-13 (2003)

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).
[11956076] Cancer Res 62(8): 2239-43 (2002)

Unique conditionally replication competent bipartite adenoviruses-cancer terminator viruses (CTV): efficacious reagents for cancer gene therapy.
[16861924] Cell Cycle 5(14): 1531-6 (2006)

Targeting gene-virotherapy of cancer and its prosperity.
[17102812] Cell Res 16(11): 879-86 (2006)

Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene.
[18413837] Clin Cancer Res 14(8): 2450-7 (2008)

Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.
[18511292] Cytokine 43(1): 34-44 (2008)

Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions.
[11956016] Eur Cytokine Netw 13(1): 5-15 (2002)

Oncolytic adenovirus-mediated MDA-7/IL-24 overexpression enhances antitumor activity in hepatocellular carcinoma cell lines.
[21134831] Hepatobiliary Pancreat Dis Int 9(6): 615-21 (2010)

Molecular Mechanisms Governing IL-24 Gene Expression.
[22536164] Immune Netw 12(1): 1-7 (2012)

IL-24 modulates IFN-gamma expression in patients with tuberculosis.
[18199488] Immunol Lett 117(1): 57-62 (2008)

Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.
[19734147] J Biol Chem 284(44): 30526-33 (2009)

Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.
[11706020] J Biol Chem 277(9): 7341-7 (2002)

Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.
[12351624] J Biol Chem 277(49): 47517-23 (2002)

Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes.
[10825166] J Biol Chem 275(32): 24436-43 (2000)

Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.
[16646087] J Cell Physiol 208(2): 298-306 (2006)

Oncolytic adenovirus armed with IL-24 Inhibits the growth of breast cancer in vitro and in vivo.
[22640485] J Exp Clin Cancer Res 31(1): 51 (2012)

Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression.
[21357535] J Immunol 186(7): 4098-109 (2011)

IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression.
[18941194] J Immunol 181(9): 6051-60 (2008)

The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.
[12055212] J Immunol 168(12): 6041-6 (2002)

Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.
[11564763] J Immunol 167(7): 3545-9 (2001)

Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer.
[21524313] J Transl Med 9(): 49 (2011)

IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.
[20216471] Melanoma Res (): (2010)

Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.
[22569271] Mol Cancer 11(1): 31 (2012)

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
[19417161] Mol Cancer Ther 8(5): 1280-91 (2009)

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
[18281515] Mol Cancer Ther 7(2): 297-313 (2008)

Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.
[19056673] Mol Cancer Ther 7(12): 3842-51 (2008)

Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.
[18723497] Mol Cancer Ther 7(8): 2528-35 (2008)

Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy.
[11471572] Mol Med 7(4): 271-82 (2001)

A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
[21119025] Mol Pharmacol 79(3): 368-80 (2011)

Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
[19910452] Mol Pharmacol 77(2): 298-310 (2010)

Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.
[20858700] Mol Pharmacol 78(6): 1096-104 (2010)

Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.
[20179672] Mol Ther 18(6): 1130-42 (2010)

Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.
[19888195] Mol Ther 18(2): 295-306 (2010)

Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo.
[12085234] Oncogene 21(29): 4558-66 (2002)

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells.
[11850799] Oncogene 21(5): 708-18 (2002)

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
[11704829] Oncogene 20(48): 7051-63 (2001)

Regulation of mda-7 gene expression during human melanoma differentiation.
[10713678] Oncogene 19(10): 1362-8 (2000)

The development of MDA-7/IL-24 as a cancer therapeutic.
[20732354] Pharmacol Ther 128(2): 375-84 (2010)

MDA-7/IL-24 Induces Bcl-2 Denitrosylation and Ubiquitin-Degradation Involved in Cancer Cell Apoptosis.
[22629368] PLoS One 7(5): e37200 (2012)

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
[21555592] Proc Natl Acad Sci U S A 108(21): 8785-90 (2011)

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.
[18599461] Proc Natl Acad Sci U S A 105(28): 9763-8 (2008)

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
[12114539] Proc Natl Acad Sci U S A 99(15): 10054-9 (2002)

The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.
[9826712] Proc Natl Acad Sci U S A 95(24): 14400-5 (1998)

The melanoma differentiation associated gene mda-7 suppresses cancer cell growth.
[8799171] Proc Natl Acad Sci U S A 93(17): 9160-5 (1996)

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.
[17208263] Toxicol Appl Pharmacol 224(3): 300-7 (2007)

Oncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines.
[20872968] World J Gastroenterol 16(37): 4677-84 (2010)

Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy.
[21995527] Acta Oncol 51(3): 285-92 (2012)

mda-7 (IL-24): signaling and functional roles.
[12395925] Biotechniques Suppl(): 30-9 (2002)

A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression.
[22588557] Br J Cancer (): (2012)

MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity.
[17828282] Cancer Gene Ther 15(1): 1-8 (2008)

Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue.
[17024233] Cancer Gene Ther 14(1): 12-8 (2007)

Role of the interleukin 24 in patients with ulcerative colitis.
[21287675] Inflamm Bowel Dis 17(10): 2209-10 (2011)

Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas.
[11668478] Int J Cancer 94(1): 54-9 (2001)

Expression of interleukin-24 and its receptor in human pancreatic myofibroblasts.
[21922126] Int J Mol Med 28(6): 993-9 (2011)

Loss of MDA-7 expression with progression of melanoma.
[11844832] J Clin Oncol 20(4): 1069-74 (2002)

Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release.
[12830052] J Thorac Cardiovasc Surg 125(6): 1328-35 (2003)

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells.
[18025283] Mol Cancer Ther 6(11): 2985-94 (2007)

Inhibition of Src kinase activity by Ad-mda7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells.
[16054437] Mol Ther 12(4): 707-15 (2005)

mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.
[15851011] Mol Ther 11(5): 724-33 (2005)

Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.
[15851010] Mol Ther 11(5): 717-23 (2005)

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.
[15585417] Mol Ther 11(1): 160-72 (2005)

Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.
[15585416] Mol Ther 11(1): 149-59 (2005)

mda-7/IL-24: exploiting cancer's Achilles' heel.
[15585401] Mol Ther 11(1): 4-18 (2005)

Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation.
[15194048] Mol Ther 9(6): 818-28 (2004)

Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells.
[15093181] Mol Ther 9(4): 510-8 (2004)

Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.
[12907144] Mol Ther 8(2): 220-9 (2003)

Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells.
[16044151] Oncogene 24(51): 7552-66 (2005)

Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells.
[15326486] Oncogene 23(45): 7571-9 (2004)

Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells.
[15273727] Oncogene 23(42): 7125-31 (2004)

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
[12606943] Oncogene 22(8): 1164-80 (2003)

mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway.
[21109977] Oncol Rep 25(1): 195-201 (2011)

mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress.
[18636209] Oncol Rep 20(2): 437-42 (2008)

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