Osmosensor

Osmosensing by bacteria: signals and membrane-based sensors.
[10066837] Microbiol Mol Biol Rev 63(1): 230-62 (1999)

Physiological and genetic responses of bacteria to osmotic stress.
[2651863] Microbiol Rev 53(1): 121-47 (1989)

Hyperosmotic activation of CNS sympathetic drive: implications for cardiovascular disease.
[20603334] J Physiol 588(Pt 18): 3375-84 (2010)

Receptor regulation of osmolyte homeostasis in neural cells.
[20498228] J Physiol 588(Pt 18): 3355-64 (2010)

Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
[17350992] Exp Physiol 92(3): 507-12 (2007)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18378772] J Cell Biol 181(1): 143-55 (2008)

TRP channels in kidney disease.
[17346947] Biochim Biophys Acta 1772(8): 928-36 (2007)

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
[21204498] (): (2007)

Impaired osmotic sensation in mice lacking TRPV4.
[12777254] Am J Physiol Cell Physiol 285(1): C96-101 (2003)

TRPV4 mediates hypotonicity-induced ATP release by the thick ascending limb.
[18684885] Am J Physiol Renal Physiol 295(4): F1090-5 (2008)

Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells.
[17699550] Am J Physiol Renal Physiol 293(5): F1699-713 (2007)

Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments.
[15026302] Am J Physiol Renal Physiol 287(1): F17-24 (2004)

Neurophysiological characterization of mammalian osmosensitive neurones.
[17350993] Exp Physiol 92(3): 499-505 (2007)

Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.
[19174160] FEBS Lett 583(4): 754-8 (2009)

A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
[16571723] J Biol Chem 281(22): 15485-95 (2006)

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
[12538589] J Biol Chem 278(13): 11520-7 (2003)

Osmoreception: perspectives on signal transduction and environmental modulation.
[22036842] Gen Comp Endocrinol 176(3): 354-60 (2012)

TRPV channels' role in osmotransduction and mechanotransduction.
[17217074] Handb Exp Pharmacol (179): 473-87 (2007)

Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.
[17170210] J Endocrinol 191(3): 515-23 (2006)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18443356] J Gen Physiol 131(5): i2 (2008)

Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.
[21994383] J Neurosci 31(41): 14669-76 (2011)

TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals.
[15961428] J Physiol 567(Pt 1): 53-8 (2005)

Osmolality-induced tuning of action potentials in trigeminal ganglion neurons.
[19444958] Neurosci Lett 452(1): 79-83 (2009)

Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons.
[19428701] Neurosci Res 64(2): 199-207 (2009)

The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons.
[18456412] Neuroscience 154(2): 482-95 (2008)

Rat Merkel cells are mechanoreceptors and osmoreceptors.
[19898622] PLoS One 4(11): e7759 (2009)

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion.
[18024594] Proc Natl Acad Sci U S A 104(48): 19138-43 (2007)

Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions.
[16537379] Proc Natl Acad Sci U S A 103(12): 4747-52 (2006)

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.
[14691263] Proc Natl Acad Sci U S A 101(1): 396-401 (2004)

Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.
[14581619] Proc Natl Acad Sci U S A 100 Suppl 2(): 14531-6 (2003)

Abnormal osmotic regulation in trpv4-/- mice.
[14581612] Proc Natl Acad Sci U S A 100(23): 13698-703 (2003)

Physiopathology of hereditary polyuric states: a molecular view of renal function.
[22802123] Swiss Med Wkly 142(): w13613 (2012)

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.
[11025659] Nat Cell Biol 2(10): 695-702 (2000)

The molecular and cellular identity of peripheral osmoreceptors.
[21262470] Neuron 69(2): 332-44 (2011)

Hypotonicity induces TRPV4-mediated nociception in rat.
[12895423] Neuron 39(3): 497-511 (2003)

Hypertonic stimulation inhibits synaptic transmission in hippocampal slices through decreasing pre-synaptic voltage-gated calcium current.
[22172932] Neurosci Lett 507(2): 106-11 (2012)

TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator.
[16213085] Pain 118(1-2): 70-9 (2005)

TRPV4 and the mammalian kidney.
[15988590] Pflugers Arch 451(1): 168-75 (2005)

TRPV4 as osmosensor: a transgenic approach.
[15952033] Pflugers Arch 451(1): 176-80 (2005)

How do kidney cells adapt to survive in hypertonic inner medulla?
[19768191] Trans Am Clin Climatol Assoc 120(-): 389-401 (2009)

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All Medline data shown were primarily retrieved from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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