Protein kinase B Akt

Physiological regulation of Akt activity and stability.
[20182580] Am J Transl Res 2(1): 19-42 (2010)

3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase.
[19568789] J Chem Biol 2(1): 11-25 (2009)

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.
[19568798] J Chem Biol 1(1-4): 49-62 (2008)

The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target.
[16540633] Cancer Res 66(6): 2889-92 (2006)

Protein kinase B/Akt at a glance.
[16339964] J Cell Sci 118(Pt 24): 5675-8 (2005)

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
[11686294] J Cell Sci 114(Pt 16): 2903-10 (2001)

AKT/PKB signaling: navigating downstream.
[17604717] Cell 129(7): 1261-74 (2007)

Akt/PKB signaling in cancer: a function in cell motility and invasion.
[16582622] Cell Cycle 5(6): 603-5 (2006)

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.
[16179727] Exp Biol Med (Maywood) 230(9): 593-605 (2005)

Akt: versatile mediator of cell survival and beyond.
[16248975] J Biochem Mol Biol 35(1): 106-15 (2002)

The survival kinases Akt and Pim as potential pharmacological targets.
[16200194] J Clin Invest 115(10): 2618-24 (2005)

PKB binding proteins. Getting in on the Akt.
[12419241] Cell 111(3): 293-303 (2002)

Unravelling the activation mechanisms of protein kinase B/Akt.
[12829245] FEBS Lett 546(1): 108-12 (2003)

Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.
[19330070] Int J Mol Sci 9(11): 2217-30 (2008)

Regulation of Akt signaling activation by ubiquitination.
[20081374] Cell Cycle 9(3): 487-97 (2010)

The regulation of cell motility and chemotaxis by phospholipid signaling.
[18287584] J Cell Sci 121(Pt 5): 551-9 (2008)

Lipid activation of protein kinases.
[19033211] J Lipid Res 50 Suppl(-): S266-71 (2009)

Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin -- an experimental elucidation of the pharmacologic action from protein-protein interaction analysis.
[18490854] J Pharmacol Sci 107(1): 15-9 (2008)

p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
[20182617] Cold Spring Harb Perspect Biol 2(2): a001057 (2010)

Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications.
[15717836] Physiol Res 54(1): 1-16 (2005)

Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.
[21317449] Oncotarget 1(7): 530-43 (2010)

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
[20399660] Trends Cell Biol 20(7): 427-34 (2010)

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.
[19130886] Semin Cancer Biol 19(1): 25-31 (2009)

Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7.
[19664228] Cell Div 4(-): 17 (2009)

Current perspectives on Akt Akt-ivation and Akt-ions.
[19596822] Exp Biol Med (Maywood) 234(11): 1264-70 (2009)

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.
[18583310] Am J Pathol 173(2): 451-62 (2008)

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
[19180501] Arthritis Rheum 60(2): 492-500 (2009)

Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.
[18000394] Autophagy 4(1): 107-9 (2008)

Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress.
[21091646] Br J Pharmacol 162(5): 1171-8 (2011)

Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression.
[16294033] Cancer Biol Ther 4(10): 1063-7 (2005)

TRB3 function in cardiac endoplasmic reticulum stress.
[20360254] Circ Res 106(9): 1516-23 (2010)

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
[17785575] Clin Cancer Res 13(17): 5183-94 (2007)

Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle.
[21505048] Endocrinology 152(6): 2206-18 (2011)

The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.
[18801901] Endocrinology 150(1): 277-85 (2009)

PHLiPPing the switch on Akt and protein kinase C signaling.
[18511290] Trends Endocrinol Metab 19(6): 223-30 (2008)

Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.
[20398329] Breast Cancer Res 12(2): 202 (2010)

Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.
[20041238] J Membr Biol 233(1-3): 35-41 (2010)

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
[18166498] Drug Resist Updat 11(1-2): 32-50 (2008)

Switching Akt: from survival signaling to deadly response.
[19319914] Bioessays 31(5): 492-5 (2009)

Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue.
[19377835] J Bioenerg Biomembr 41(2): 169-80 (2009)

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