Sepsis

Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)).
[20628653] Ger Med Sci 8(-): Doc14 (2010)

Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses.
[12625170] Am J Crit Care 12(2): 120-33; quiz 134-5 (2003)

Surviving sepsis: a guide to the guidelines.
[18598386] Crit Care 12(3): 162 (2008)

Diagnosis and treatment of severe sepsis.
[18269689] Crit Care 11 Suppl 5(-): S2 (2007)

Rescue therapy in septic shock--is terlipressin the last frontier?
[16584529] Crit Care 10(2): 131 (2006)

Clinical review: Vasopressin and terlipressin in septic shock patients.
[15774080] Crit Care 9(2): 212-22 (2005)

Bench-to-bedside review: sepsis is a disease of the microcirculation.
[15566617] Crit Care 8(6): 462-8 (2004)

Clinical review: corticotherapy in sepsis.
[15025773] Crit Care 8(2): 122-9 (2004)

Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide.
[12974969] Crit Care 7(5): 359-73 (2003)

Clinical review: Hypertonic saline resuscitation in sepsis.
[12398781] Crit Care 6(5): 418-23 (2002)

The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock.
[12398771] Crit Care 6(5): 384-6 (2002)

The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock.
[12398770] Crit Care 6(5): 381-3 (2002)

Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
[12720559] Crit Care 7(2): 130-8 (2003)

Science review: role of coagulation protease cascades in sepsis.
[12720558] Crit Care 7(2): 123-9 (2003)

Clinical review: Myocardial depression in sepsis and septic shock.
[12493071] Crit Care 6(6): 500-8 (2002)

Critical care in the emergency department: severe sepsis and septic shock.
[16921089] Emerg Med J 23(9): 713-7 (2006)

The pathogenesis and molecular biology of sepsis.
[16930110] Crit Care Resusc 8(3): 227-9 (2006)

Recent insights into the pathogenesis of severe sepsis.
[16548817] Crit Care Resusc 7(1): 32-9 (2005)

Metabolic acidosis in patients with sepsis: epiphenomenon or part of the pathophysiology?
[16556122] Crit Care Resusc 6(3): 197-203 (2004)

Catecholamines in the treatment of septic shock: effects beyond perfusion.
[16563117] Crit Care Resusc 5(4): 270-6 (2003)

Role of KATP channels in sepsis.
[16963005] Cardiovasc Res 72(2): 220-30 (2006)

The haematological manifestations of sepsis.
[9511082] J Antimicrob Chemother 41 Suppl A(-): 17-24 (1998)

Cardiovascular alterations in septic shock.
[9511081] J Antimicrob Chemother 41 Suppl A(-): 9-15 (1998)

Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock.
[12857774] Clin Microbiol Rev 16(3): 379-414 (2003)

Gram-negative sepsis: a dilemma of modern medicine.
[8457980] Clin Microbiol Rev 6(1): 57-68 (1993)

Quantitative aspects of septicemia.
[2200606] Clin Microbiol Rev 3(3): 269-79 (1990)

Statins for sepsis: a critical and updated review.
[19416304] Clin Microbiol Infect 15(4): 325-34 (2009)

Activated protein C for the treatment of severe sepsis.
[19416303] Clin Microbiol Infect 15(4): 319-24 (2009)

The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis.
[19416302] Clin Microbiol Infect 15(4): 308-18 (2009)

Non-antibiotic strategies for sepsis.
[19416301] Clin Microbiol Infect 15(4): 302-7 (2009)

Sepsis: rethinking the approach to clinical research.
[18171697] J Leukoc Biol 83(3): 471-82 (2008)

Inflammation, endothelium, and coagulation in sepsis.
[18032692] J Leukoc Biol 83(3): 536-45 (2008)

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis.
[18088344] J Thromb Haemost 6(3): 415-20 (2008)

The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
[11956648] Int J Mol Med 9(5): 443-9 (2002)

Mechanism of hepatocellular dysfunction during sepsis: the role of gut-derived norepinephrine (review).
[10762647] Int J Mol Med 5(5): 457-65 (2000)

Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity.
[16247103] CMAJ 173(9): 1054-65 (2005)

Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials.
[18439194] Acad Emerg Med 15(5): 399-413 (2008)

New therapies for sepsis: focus on the interleukin (IL)12 family member IL27.
[17934090] Ann Rheum Dis 66 Suppl 3(-): iii29-31 (2007)

Physiological monitoring for critically ill patients: testing a predictive model for the early detection of sepsis.
[17322011] Am J Crit Care 16(2): 122-30; quiz 131 (2007)

Sepsis: definition, epidemiology, and diagnosis.
[17962288] BMJ 335(7625): 879-83 (2007)

Management of sepsis.
[17974689] BMJ 335(7626): 929-32 (2007)

Managing bloodstream infections in patients who have short-term central venous catheters.
[21199902] Cleve Clin J Med 78(1): 10-7 (2011)

The host response to sepsis and developmental impact.
[20421258] Pediatrics 125(5): 1031-41 (2010)

Mechanisms and regulation of the gene-expression response to sepsis.
[20478944] Pediatrics 125(6): 1248-58 (2010)

Managing the nervous system effects of sepsis.
[17494774] Chest 131(5): 1273-4 (2007)

Fluid therapy in resuscitated sepsis: less is more.
[18187750] Chest 133(1): 252-63 (2008)

Staphylococcus aureus bloodstream infections: definitions and treatment.
[19374581] Clin Infect Dis 48 Suppl 4(-): S254-9 (2009)

Clinical consensus conference: survey on Gram-positive bloodstream infections with a focus on Staphylococcus aureus.
[19374582] Clin Infect Dis 48 Suppl 4(-): S260-70 (2009)

Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis.
[19489712] Clin Infect Dis 49(1): 93-101 (2009)

The role of natural killer cells in sepsis.
[21629707] J Biomed Biotechnol 2011(-): 986491 (2011)

Effects of recombinant human activated protein C in human models of endotoxin administration.
[16222045] Proc Am Thorac Soc 2(3): 243-7 (2005)

Sepsis-induced degradation of endothelial glycocalix.
[20495770] ScientificWorldJournal 10(-): 917-23 (2010)

Insights into sepsis therapeutic design based on the apoptotic death pathway.
[21081836] J Pharmacol Sci 114(4): 354-65 (2010)

Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy.
[16823257] J Pharmacol Sci 101(3): 189-98 (2006)

Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target.
[20002097] Br J Pharmacol 159(2): 253-64 (2010)

Protective mechanisms of activated protein C in severe inflammatory disorders.
[19466992] Br J Pharmacol 158(4): 1034-47 (2009)

Toward resolving the challenges of sepsis diagnosis.
[15166107] Clin Chem 50(8): 1301-14 (2004)

Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study.
[19696442] Am J Respir Crit Care Med 180(9): 861-6 (2009)

Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis.
[21310070] Crit Care 15(1): R58 (2011)

Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis.
[20804578] Crit Care 14(4): 230 (2010)

Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective.
[20626892] Crit Care 14(4): R134 (2010)

Corticosteroids for sepsis: registry versus Cochrane systematic review!
[20727225] Crit Care 14(4): 185 (2010)

Bench to bedside: A role for erythropoietin in sepsis.
[20727227] Crit Care 14(4): 227 (2010)

Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry.
[20525247] Crit Care 14(3): R102 (2010)

Cerebral perfusion in sepsis.
[20236459] Crit Care 14(2): 215 (2010)

Sepsis biomarkers: a review.
[20144219] Crit Care 14(1): R15 (2010)

Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock--does the dose matter?
[19519961] Crit Care 13(3): 214 (2009)

Bench-to-bedside review: ventilatory abnormalities in sepsis.
[19216724] Crit Care 13(1): 202 (2009)

Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis.
[18226173] Crit Care 12(1): 201 (2008)

Cellular processes in sepsis.
[19005868] Swiss Med Wkly 138(43-44): 629-34 (2008)

Management of severe sepsis of abdominal origin.
[17966743] Scand J Surg 96(3): 184-96 (2007)

Revisiting steroid treatment for septic shock: molecular actions and clinical effects--a review.
[19722073] Mem Inst Oswaldo Cruz 104(4): 531-48 (2009)

Molecular microbiological methods in the diagnosis of neonatal sepsis.
[20818947] Expert Rev Anti Infect Ther 8(9): 1037-48 (2010)

Biomarkers for pediatric sepsis and septic shock.
[21171879] Expert Rev Anti Infect Ther 9(1): 71-9 (2011)

Treatment of septic shock and use of drotrecogin alfa (activated) in children.
[19735218] Expert Rev Anti Infect Ther 7(7): 769-72 (2009)

Pharmacologic support of infants and children in septic shock.
[17530137] J Pediatr (Rio J) 83(2 Suppl): S36-45 (2007)

New guidelines for the clinical management of febrile neutropenia and sepsis in pediatric oncology patients.
[17530138] J Pediatr (Rio J) 83(2 Suppl): S54-63 (2007)

What tests can help diagnose and estimate the severity of sepsis?
[17676234] J Pediatr (Rio J) 83(4): 297-8 (2007)

Adrenal function in sepsis and septic shock.
[17987246] J Pediatr (Rio J) 83(5 Suppl): S155-62 (2007)

Recent insights into the pathogenesis of bacterial sepsis.
[20421654] Neth J Med 68(4): 147-52 (2010)

Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections.
[12149414] J Leukoc Biol 72(2): 239-48 (2002)

The chronic consequences of severe sepsis.
[14557384] J Leukoc Biol 75(3): 408-12 (2004)

The roles of insulin and hyperglycemia in sepsis pathogenesis.
[14657207] J Leukoc Biol 75(3): 413-21 (2004)

A key role of C5a/C5aR activation for the development of sepsis.
[12960283] J Leukoc Biol 74(6): 966-70 (2003)

Editorial: Mouse models to study sepsis syndrome in humans.
[19643738] J Leukoc Biol 86(2): 199-201 (2009)

Regulatory T cell populations in sepsis and trauma.
[17913974] J Leukoc Biol 83(3): 523-35 (2008)

The heart and circulation in severe sepsis.
[15121730] Br J Anaesth 93(1): 114-20 (2004)

New developments in septic acute kidney injury.
[20533855] Physiol Res 59(6): 859-69 (2010)

Sepsis-associated encephalopathy: not just delirium.
[22012058] Clinics (Sao Paulo) 66(10): 1825-31 (2011)

Sepsis: from bench to bedside.
[18297215] Clinics (Sao Paulo) 63(1): 109-20 (2008)

New technology for rapid molecular diagnosis of bloodstream infections.
[20465496] Expert Rev Mol Diagn 10(4): 399-415 (2010)

Harmful molecular mechanisms in sepsis.
[18802444] Nat Rev Immunol 8(10): 776-87 (2008)

Liver perfusion in sepsis, septic shock, and multiorgan failure.
[18484618] Anat Rec (Hoboken) 291(6): 714-20 (2008)

Newer approaches to the diagnosis of early onset neonatal sepsis.
[16632649] Arch Dis Child Fetal Neonatal Ed 91(3): F208-12 (2006)

Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.
[18695372] Curr Opin Hematol 15(5): 487-93 (2008)

Microcirculatory alterations: potential mechanisms and implications for therapy.
[21906380] Ann Intensive Care 1(1): 27 (2011)

The apoptotic pathway as a therapeutic target in sepsis.
[17430119] Curr Drug Targets 8(4): 493-500 (2007)

Pathophysiology and treatment of septic shock in neonates.
[20569817] Clin Perinatol 37(2): 439-79 (2010)

The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.
[20569812] Clin Perinatol 37(2): 355-74 (2010)

The microcirculation in sepsis.
[20640135] Indian J Anaesth 53(3): 281-93 (2009)

Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness.
[17577136] Shock 28(4): 384-93 (2007)

Novel HMGB1-inhibiting therapeutic agents for experimental sepsis.
[19333143] Shock 32(4): 348-57 (2009)

Advances in understanding sepsis.
[18289433] Eur J Anaesthesiol Suppl 42(-): 146-53 (2008)

Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response.
[19519586] Recent Pat Inflamm Allergy Drug Discov 3(2): 96-112 (2009)

Young infant sepsis: aetiology, antibiotic susceptibility and clinical signs.
[17658566] Trans R Soc Trop Med Hyg 101(10): 959-66 (2007)

Epigenetic regulation of immune cell functions during post-septic immunosuppression.
[21048427] Epigenetics 6(3): 273-83 (2011)

Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis.
[20733044] Antimicrob Agents Chemother 54(11): 4851-63 (2010)

Biomarkers for late-onset neonatal sepsis.
[20828428] Genome Med 2(9): 58 (2010)

Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis.
[21526108] J Res Med Sci 15(6): 348-58 (2010)

Canadian Association of Emergency Physicians Sepsis Guidelines: the optimal management of severe sepsis in Canadian emergency departments.
[18826733] CJEM 10(5): 443-59 (2008)

Role of C5 activation products in sepsis.
[21170490] ScientificWorldJournal 10(): 2395-402 (2010)

The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
[24391721] PLoS One 8(12):e82775 (2013)

Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury.
[23275604] J Immunol 190(3):1264-75 (2013)

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.
[24484547] J Transl Med 12():32 (2014)

Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo.
[24516666] PLoS One 9(2):e88501 (2014)

Clinical controversies in the management of critically ill patients with severe sepsis: resuscitation fluids and glucose control.
[23921249] Virulence 5(1):200-5 (2014)

Inflammation and infection in critical care medicine.
[24623961] Mediators Inflamm 2014():456256 (2014)

Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin Can Reflect Sepsis Severity and Predict Prognosis: A Prospective Cohort Study.
[24672147] Mediators Inflamm 2014(): (2014)

Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis.
[19242342] Crit Care Med 37(4):1397-402 (2009)

Procalcitonin clearance for early prediction of survival in critically ill patients with severe sepsis.
[24719759] Crit Care Res Pract 2014():819034 (2014)

Prognostic categorization of intensive care septic patients.
[24701404] World J Crit Care Med 1(3):67-79 (2012)

Severe sepsis and septic shock in the elderly: An overview.
[24701398] World J Crit Care Med 1(1):23-30 (2012)

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