Sirtuin

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Sirtuin

LE WE PMID CA

Sirtuin

2549

Sirtuin

14 3 3

Alzheimer s disease

AMP activated protein kinase

BMAL1

Circadian clock

DAF16

DNA (Repair and Toxicology)

Heterochromatin island hypothesis

Histone deacetylase

Long life

Mitochondria (BASKET)

NAD

Neoplasia (Tumor biology and immunology)

Nicotinamide phosphoribosyltransferase

PER2

Rpd3 Hda1 protein family

Sirt3

SIRT4

SIRT5

Sirtuin

Vorinostat ttHDAC

2006 1	Neuronal protection by sirtuins in Alzheimer's disease. [16219030] J Neurochem 96(2): 305-13 (2006)
2008 2	SIRT1: roles in aging and cancer. [19017485] BMB Rep 41(11): 751-6 (2008)
2009 3	SIRT1, is it a tumor promoter or tumor suppressor? [19173036] Int J Biol Sci 5(2): 147-52 (2009)
2009 4	The conserved role of sirtuins in chromatin regulation. [19378253] Int J Dev Biol 53(2-3): 303-22 (2009)
2008 5	Mechanisms and molecular probes of sirtuins. [18940661] Chem Biol 15(10): 1002-13 (2008)
2007 6	Sirtuins in mammals: insights into their biological function. [17447894] Biochem J 404(1): 1-13 (2007)
2008 7	Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. [18340017] Circ Res 102(5): 519-28 (2008)
2004 8	Sir-viving cardiac stress: cardioprotection mediated by a longevity gene. [15539638] Circ Res 95(10): 953-6 (2004)
2005 9	Small molecule regulation of Sir2 protein deacetylases. [16156783] FEBS J 272(18): 4607-16 (2005)
2008 10	Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. [18036349] FEBS Lett 582(1): 46-53 (2008)
2006 11	Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. [17079682] Genes Dev 20(21): 2913-21 (2006)
2003 12	How does calorie restriction work? [12569120] Genes Dev 17(3): 313-21 (2003)
2000 13	Sir2 links chromatin silencing, metabolism, and aging. [10809662] Genes Dev 14(9): 1021-6 (2000)
2004 14	Sirtuins: Sir2-related NAD-dependent protein deacetylases. [15128440] Genome Biol 5(5): 224 (2004)
2008 15	Acetylation in nuclear receptor signaling and the role of sirtuins. [18165438] Mol Endocrinol 22(3): 539-45 (2008)
2007 16	Sirtuin functions in health and disease. [17456799] Mol Endocrinol 21(8): 1745-55 (2007)
2000 17	The Sir2 protein family: A novel deacetylase for gene silencing and more. [11114164] Proc Natl Acad Sci U S A 97(26): 14030-2 (2000)
1999 18	Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality. [10630591] Toxicol Sci 52(2 Suppl): 56-60 (1999)
2006 19	Sirtuins in aging and age-related disease. [16873059] Cell 126(2): 257-68 (2006)
2005 20	Calorie restriction--the SIR2 connection. [15734680] Cell 120(4): 473-82 (2005)
2008 21	Conserved metabolic regulatory functions of sirtuins. [18249170] Cell Metab 7(2): 104-12 (2008)
2005 22	Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. [15862287] FEBS Lett 579(12): 2541-5 (2005)
2011 23	Identification of specific and semi-specific SIRT inhibitors through computer-aided studies. [21937768] Aging (Albany NY) 3(9): 819-20 (2011)
2011 24	Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. [21946623] Aging (Albany NY) 3(9): 829-35 (2011)
2011 25	Does hypothalamic SIRT1 regulate aging? [21464518] Aging (Albany NY) 3(3): 325-8 (2011)
2011 26	Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. [21483037] Aging (Albany NY) 3(4): 444-9 (2011)
2010 27	A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1. [21155626] Altern Med Rev 15(3): 245-63 (2010)
2010 28	Sirtuin chemical mechanisms. [20132909] Biochim Biophys Acta 1804(8): 1591-603 (2010)
2010 29	"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. [19897060] Biochim Biophys Acta 1804(8): 1584-90 (2010)
2010 30	Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction. [19818879] Biochim Biophys Acta 1804(8): 1567-75 (2010)
2010 31	Structural basis for sirtuin function: what we know and what we don't. [19766737] Biochim Biophys Acta 1804(8): 1604-16 (2010)
2009 32	From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. [19289152] Biochim Biophys Acta 1790(10): 997-1004 (2009)
2006 33	A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins. [17172829] Cell Cycle 5(22): 2588-91 (2006)
2010 34	At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. [20458180] Cell Cycle 9(10): 1907-12 (2010)
2008 35	Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. [19029811] Cell Cycle 7(23): 3669-79 (2008)
2010 36	Sirtuins and their relevance to the kidney. [20595677] J Am Soc Nephrol 21(10): 1620-7 (2010)
2010 37	The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. [20007326] Endocr Rev 31(2): 194-223 (2010)
2008 38	Transcriptional targets of sirtuins in the coordination of mammalian physiology. [18468877] Curr Opin Cell Biol 20(3): 303-9 (2008)
2011 39	Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis. [22016654] Int J Mol Sci 12(9): 6226-39 (2011)
2008 40	The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. [18292778] Nat Rev Mol Cell Biol 9(3): 206-18 (2008)
2009 41	Function of sirtuins in biological tissues. [19301279] Anat Rec (Hoboken) 292(4): 536-43 (2009)
2010 42	A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. [20085812] Pharmacol Res 62(1): 42-7 (2010)
2010 43	Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis. [20138996] Pharmacol Res 62(1): 48-54 (2010)
2010 44	Mammalian sirtuins: biological insights and disease relevance. [20078221] Annu Rev Pathol 5(-): 253-95 (2010)
2010 45	Dietary interventions to extend life span and health span based on calorie restriction. [20371545] J Gerontol A Biol Sci Med Sci 65(7): 695-703 (2010)
2010 46	Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. [20025641] J Pineal Res 48(1): 9-19 (2010)
2011 47	The dual role of sirtuins in cancer. [21941620] Genes Cancer 2(6): 648-62 (2011)
2009 48	Histone deacetylase inhibitors: Potential in cancer therapy. [19459166] J Cell Biochem 107(4): 600-8 (2009)
2010 49	Resveratrol, sirtuins, and the promise of a DR mimetic. [20219519] Mech Ageing Dev 131(4): 261-9 (2010)
2010 50	The molecular genetics of sirtuins: association with human longevity and age-related diseases. [21537393] Int J Mol Epidemiol Genet 1(3): 214-25 (2010)
2010 51	Effects of calorie restriction on life span of microorganisms. [20721547] Appl Microbiol Biotechnol 88(4): 817-28 (2010)
2010 52	A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2. [21194247] Altern Med Rev 15(4): 313-28 (2010)
2010 53	The sirtuins in the pathogenesis of cancer. [22704201] Clin Epigenetics 1(3-4): 71-83 (2010)
2010 54	Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. [20863707] Trends Biochem Sci 35(12): 669-75 (2010)

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