beta cell (Pancreas)

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.
[18812463] Am J Physiol Endocrinol Metab 296(1): E1-10 (2009)

Channel regulation of glucose sensing in the pancreatic beta-cell.
[18940941] Am J Physiol Endocrinol Metab 295(6): E1298-306 (2008)

Metabolic cycling in control of glucose-stimulated insulin secretion.
[18728221] Am J Physiol Endocrinol Metab 295(6): E1287-97 (2008)

The ryanodine receptor calcium channel of beta-cells: molecular regulation and physiological significance.
[11978625] Diabetes 51(5): 1299-309 (2002)

Metabolic oscillations in beta-cells.
[11815475] Diabetes 51 Suppl 1(-): S152-61 (2002)

Control mechanisms of the oscillations of insulin secretion in vitro and in vivo.
[11815474] Diabetes 51 Suppl 1(-): S144-51 (2002)

Clinical characterization of insulin secretion as the basis for genetic analyses.
[11815470] Diabetes 51 Suppl 1(-): S122-9 (2002)

Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
[11815469] Diabetes 51 Suppl 1(-): S117-21 (2002)

Phasic insulin release and metabolic regulation in type 2 diabetes.
[11815468] Diabetes 51 Suppl 1(-): S109-16 (2002)

Physiological consequences of phasic insulin release in the normal animal.
[11815467] Diabetes 51 Suppl 1(-): S103-8 (2002)

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.
[11815463] Diabetes 51 Suppl 1(-): S83-90 (2002)

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
[11815462] Diabetes 51 Suppl 1(-): S74-82 (2002)

Beta-cell protein kinases and the dynamics of the insulin response to glucose.
[11815461] Diabetes 51 Suppl 1(-): S68-73 (2002)

Signals and pools underlying biphasic insulin secretion.
[11815460] Diabetes 51 Suppl 1(-): S60-7 (2002)

Modeling phasic insulin release: immediate and time-dependent effects of glucose.
[11815459] Diabetes 51 Suppl 1(-): S53-9 (2002)

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.
[11815456] Diabetes 51 Suppl 1(-): S37-42 (2002)

Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.
[11815455] Diabetes 51 Suppl 1(-): S33-6 (2002)

Molecular determinants of regulated exocytosis.
[11815450] Diabetes 51 Suppl 1(-): S3-11 (2002)

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.
[11147773] Diabetes 50(1): 1-11 (2001)

Triggering and amplifying pathways of regulation of insulin secretion by glucose.
[11078440] Diabetes 49(11): 1751-60 (2000)

Synaptotagmins bind calcium to release insulin.
[18713958] Am J Physiol Endocrinol Metab 295(6): E1279-86 (2008)

Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion.
[17666486] Am J Physiol Endocrinol Metab 293(4): E890-900 (2007)

Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests.
[17341552] Am J Physiol Endocrinol Metab 293(1): E1-E15 (2007)

Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.
[15985450] Am J Physiol Endocrinol Metab 289(5): E839-48 (2005)

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.
[15585595] Am J Physiol Endocrinol Metab 288(1): E1-15 (2005)

First-phase insulin secretion: does it exist in real life? Considerations on shape and function.
[15308473] Am J Physiol Endocrinol Metab 287(3): E371-85 (2004)

Phosphorylated inositol compounds in beta -cell stimulus-response coupling.
[12424101] Am J Physiol Endocrinol Metab 283(6): E1113-22 (2002)

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues.
[15561921] Diabetes 53 Suppl 3(): S48-58 (2004)

Five stages of evolving beta-cell dysfunction during progression to diabetes.
[15561905] Diabetes 53 Suppl 3(): S16-21 (2004)

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.
[12475782] Diabetes 51 Suppl 3(): S394-404 (2002)

Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.
[12475781] Diabetes 51 Suppl 3(): S389-93 (2002)

The succinate mechanism of insulin release.
[12196457] Diabetes 51(9): 2669-76 (2002)

Transcription factors regulating beta-cell function.
[17062882] Eur J Endocrinol 155(5): 671-9 (2006)

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.
[17293440] J Mol Endocrinol 38(1-2): 193-206 (2007)

Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.
[20217502] Adv Exp Med Biol 654(-): 261-79 (2010)

Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.
[20628025] Am J Physiol Endocrinol Metab 299(4): E517-32 (2010)

Glucolipotoxicity of the pancreatic beta cell.
[19715772] Biochim Biophys Acta 1801(3): 289-98 (2010)

Rab27a, actin and beta-cell endocytosis.
[21187662] Endocr J 58(1): 1-6 (2011)

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes [Review].
[21908934] Endocr J 58(10): 819-25 (2011)

The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.
[20164242] Endocr Rev 31(3): 343-63 (2010)

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.
[18314421] Endocr Rev 29(3): 303-16 (2008)

Glucolipotoxicity: fuel excess and beta-cell dysfunction.
[18048763] Endocr Rev 29(3): 351-66 (2008)

The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.
[20519313] J Physiol 588(Pt 17): 3201-9 (2010)

Novel aspects of the molecular mechanisms controlling insulin secretion.
[18511483] J Physiol 586(14): 3313-24 (2008)

Regulation of pancreatic beta-cell mass.
[16183912] Physiol Rev 85(4): 1255-70 (2005)

Pancreatic beta-cells: from generation to regeneration.
[20688184] Semin Cell Dev Biol 21(8): 838-44 (2010)

Physiological regulation of the pancreatic {beta}-cell: functional insights for understanding and therapy of diabetes.
[17272356] Exp Physiol 92(3): 481-96 (2007)

Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.
[20551594] Proc Jpn Acad Ser B Phys Biol Sci 86(6): 563-77 (2010)

ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells.
[19622788] Am J Physiol Endocrinol Metab 297(3): E812-21 (2009)

Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.
[17662254] Biochem Pharmacol 75(2): 335-45 (2008)

The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion.
[21785227] Endocr J 58(12): 1021-8 (2011)

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.
[18751967] Diabetologia 51(12): 2252-62 (2008)

Pleiotropic effects of GIP on islet function involve osteopontin.
[21810601] Diabetes 60(9): 2424-33 (2011)

MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications.
[21709277] Diabetes 60(7): 1825-31 (2011)

Diabetes complications: the microRNA perspective.
[21709278] Diabetes 60(7): 1832-7 (2011)

Beta-cell growth and regeneration: replication is only part of the story.
[20876724] Diabetes 59(10): 2340-8 (2010)

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.
[12606496] Diabetes 52(3): 581-7 (2003)

Stress hypERactivation in the β-cell.
[21099287] Islets 2(1): 1-9 (2010)

Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration.
[21099270] Islets 1(3): 177-84 (2009)

Endothelial cells in pancreatic islet development and function.
[21084843] Islets 1(1): 2-9 (2009)

Identification of a novel mechanism regulating β-cell mass: neuronal relay from the liver to pancreatic β-cells.
[21084852] Islets 1(1): 75-7 (2009)

Potential pathways to restore β-cell mass: pluripotent stem cells, reprogramming, and endogenous regeneration.
[21800022] Curr Diab Rep 11(5): 392-401 (2011)

Review: pancreatic beta-cell neogenesis revisited.
[15203882] Exp Diabesity Res 5(2): 111-21 (2004)

Pulsatility of insulin release--a clinically important phenomenon.
[19961265] Ups J Med Sci 114(4): 193-205 (2009)

Regulation of insulin secretion: role of mitochondrial signalling.
[20225132] Diabetologia 53(6): 1019-32 (2010)

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.
[19326096] Diabetologia 52(6): 1003-12 (2009)

Pdx1 and other factors that regulate pancreatic beta-cell survival.
[19817786] Diabetes Obes Metab 11 Suppl 4(-): 30-7 (2009)

Physiologic implications of phosphoinositides and phospholipase C in the regulation of insulin secretion.
[20354339] J Nutr Sci Vitaminol (Tokyo) 56(1): 1-8 (2010)

Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.
[21094904] Vitam Horm 84(-): 279-302 (2010)

Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.
[12832692] Stem Cells 21(4): 377-88 (2003)

Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation.
[20219891] Mol Endocrinol 24(8): 1501-11 (2010)

Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4.
[20053958] Am J Physiol Regul Integr Comp Physiol 298(3): R517-31 (2010)

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
[19501608] Toxicol Appl Pharmacol 244(1): 77-83 (2010)

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells.
[20500788] Nutr Rev 68(5): 270-9 (2010)

Microenvironmental stimuli for proliferation of functional islet beta-cells.
[24594290] Cell Biosci 4(1):12 (2014)

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