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mTORC1
LE WE PMID CA
mTORC19626mTORC1

Amino acid (Depletion)

Asparaginase

ATG7

Autophagy

Cell polarity

Farnesyl transferase

Glucose (Depletion)

MTOR

mTORC1

mTORC2

Neoplasia (Carcinogenesis)

Neuron (Axon)

Nutrient sensing

PI3K

Protein kinase B Akt

RHEB

SAD

Statin

TSC1 Hamartin

TSC2 Tuberin

2010  
1
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
[20388784] Cancer Res 70(8): 3287-98 (2010)
2008  
2
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
[18466115] Biochem J 412(2): 179-90 (2008)
2008  
3
The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.
[18794342] Genes Dev 22(18): 2447-53 (2008)
2010  
4
Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.
[21317449] Oncotarget 1(7): 530-43 (2010)
2012  
5
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.
[22294621] Circulation 125(9): 1134-46 (2012)
2011  
6
Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin.
[21561413] Curr Drug Targets 12(8): 1223-31 (2011)
2010  
7
mTOR signaling: at the crossroads of plasticity, memory and disease.
[19963289] Trends Neurosci 33(2): 67-75 (2010)
2010  
8
The complexes of mammalian target of rapamycin.
[20491627] Curr Protein Pept Sci 11(6): 409-24 (2010)
2011  
9
mTORC1 signaling: what we still don't know.
[21138990] J Mol Cell Biol 3(4): 206-20 (2011)
PMC   
10
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
[23842089] Proc Natl Acad Sci U S A 110(31):12661-6 (2013)

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All Medline data shown were primarily retrieved from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.


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