Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38 Ferrero E; Malavasi FJ Leukoc Biol 1999[Feb]; 65 (2): 151-61Human CD38 is a 45-kDa type II membrane glycoprotein with an intricate pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression in cells of nonvascular origin. CD38 is a member of a nascent eukaryotic gene family encoding cytosolic and membrane-bound enzymes whose substrate is NAD, a coenzyme ubiquitously distributed in nature. Functionally, CD38 is an eclectic molecule with the ability not only to catalyze but also to signal, to mobilize calcium, and to adhere to itself, to hyaluronan, and to other ligands. Interaction with CD38 on various leukocyte subpopulations has profound though diverse consequences on their life-span, but these effects seem to be independent of the enzymatic activity of the molecule. CD38 challenges our expectations of a surface molecule and we must sift through its many guises to unmask its true nature.|*Antigens, CD[MESH]|ADP-ribosyl Cyclase[MESH]|ADP-ribosyl Cyclase 1[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Antigens, Differentiation/chemistry/genetics/*physiology[MESH]|Chromosome Mapping[MESH]|Chromosomes, Human, Pair 4[MESH]|Gene Expression Regulation[MESH]|HL-60 Cells/chemistry/physiology[MESH]|Hematopoietic Stem Cells/cytology/metabolism[MESH]|Humans[MESH]|Lymphocytes/*chemistry/physiology[MESH]|Membrane Glycoproteins[MESH]|Molecular Sequence Data[MESH]|NAD+ Nucleosidase/chemistry/genetics/*physiology[MESH]|NAD/metabolism[MESH]|Organ Specificity[MESH]|Polymorphism, Genetic[MESH]|Receptors, Cell Surface/chemistry/genetics/*physiology[MESH] |
