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Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development Kong YY; Boyle WJ; Penninger JMImmunol Cell Biol 1999[Apr]; 77 (2): 188-93The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.|*Receptors, Cytoplasmic and Nuclear[MESH]|Animals[MESH]|Carrier Proteins/immunology/*metabolism[MESH]|Embryonic and Fetal Development[MESH]|Glycoproteins/immunology/*metabolism[MESH]|Humans[MESH]|Immune System/immunology[MESH]|Lymph Nodes/*growth & development/immunology[MESH]|Membrane Glycoproteins/immunology/*metabolism[MESH]|Osteoclasts/*cytology/metabolism[MESH]|Osteoprotegerin[MESH]|RANK Ligand[MESH]|Receptor Activator of Nuclear Factor-kappa B[MESH]|Receptors, Tumor Necrosis Factor/immunology/*metabolism[MESH] |
