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Primary sclerosing cholangitis: MR imaging features Ito K; Mitchell DG; Outwater EK; Blasbalg RAJR Am J Roentgenol 1999[Jun]; 172 (6): 1527-33OBJECTIVE: The purpose of this study was to evaluate the spectrum of MR imaging features of primary sclerosing cholangitis. MATERIALS AND METHODS: A retrospective review was performed of MR imaging findings including MR cholangiography and multiphasic contrast-enhanced dynamic sequences in 22 patients with primary sclerosing cholangitis. MR imaging analysis included abnormalities of intra- and extrahepatic bile ducts, abnormalities of liver parenchyma, changes in liver morphology, and lymphadenopathy. RESULTS: Abnormal findings of bile ducts were seen in all 22 patients; the most common finding was intrahepatic bile duct dilatation (77%), followed by intrahepatic bile duct stenosis (64%), extrahepatic bile duct wall enhancement (67%), extrahepatic bile duct wall thickening (50%), extrahepatic bile duct stenosis (50%), and intrahepatic bile duct beading (36%). Increased enhancement of the liver parenchyma on dynamic arterial-phase images, predominantly in the peripheral areas of the liver, was identified in 56% of patients. Other findings included periportal lymphadenopathy (77%), periportal high signal intensity on T2-weighted images (68%), hypertrophy of the caudate lobe (68%), and abnormal hyperintensity of the liver parenchyma on T1-weighted images (23%). CONCLUSION: On MR imaging, primary sclerosing cholangitis showed several characteristic features, including bile duct abnormalities and increased enhancement of the liver parenchyma. MR cholangiography and contrast-enhanced dynamic MR techniques are useful for revealing intra- and extrahepatic signs of primary sclerosing cholangitis.|*Magnetic Resonance Imaging/instrumentation/methods[MESH]|Adult[MESH]|Aged[MESH]|Bile Ducts/pathology[MESH]|Cholangiopancreatography, Endoscopic Retrograde[MESH]|Cholangitis, Sclerosing/*diagnosis[MESH]|Contrast Media[MESH]|Female[MESH]|Gadolinium DTPA[MESH]|Humans[MESH]|Liver Cirrhosis/diagnosis[MESH]|Liver/pathology[MESH]|Lymph Nodes/pathology[MESH]|Male[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH] |
