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Drugs of abuse and brain gene expression Torres G; Horowitz JMPsychosom Med 1999[Sep]; 61 (5): 630-50Addictive drugs like cocaine, ethanol, and morphine activate signal transduction pathways that regulate brain gene expression. Such regulation is modulated by the presence of certain transcription factor proteins present in a given neuron. This article summarizes the effects of several addictive drugs on transcriptional processes contributing to the development of a drug-dependent state. The characterization of drug-induced changes in gene expression shows promise for improving our understanding of drug-addiction phenomena and cellular modes of cocaine, ethanol, and morphine action.|Animals[MESH]|Brain/*drug effects/*metabolism[MESH]|Central Nervous System Depressants/adverse effects/*metabolism[MESH]|Cocaine/adverse effects/*metabolism[MESH]|Dopamine Uptake Inhibitors/adverse effects/*metabolism[MESH]|Ethanol/adverse effects/*metabolism[MESH]|Humans[MESH]|Morphine/adverse effects/*metabolism[MESH]|Narcotics/adverse effects/*metabolism[MESH]|Signal Transduction/drug effects[MESH]|Substance-Related Disorders/etiology/*metabolism[MESH]|Transcription Factors/drug effects[MESH]|Transcription, Genetic/*drug effects[MESH] |
