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Coexistent holoprosencephaly and Chiari II malformation Rollins N; Joglar J; Perlman JAJNR Am J Neuroradiol 1999[Oct]; 20 (9): 1678-81Chiari II malformations and holoprosencephaly have been considered to be brain malformations that differ with respect to teratogenic insult, embryologic mechanism, and morphology. We herein describe coexistent Chiari II malformation and holoprosencephaly that occurred in a viable infant. A review of the literature regarding Chiari II malformations and holoprosencephaly suggests that a disturbance to the mesenchyme in early embryologic life may be the cause of both malformations.|*Magnetic Resonance Imaging[MESH]|Arnold-Chiari Malformation/*complications/diagnosis/pathology[MESH]|Brain/abnormalities/pathology[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Holoprosencephaly/*complications/diagnosis/pathology[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Meningomyelocele/complications/diagnosis/pathology[MESH] |
