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Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells Colonna M; Nakajima H; Cella MJ Leukoc Biol 1999[Nov]; 66 (5): 718-22We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.|*Signal Transduction[MESH]|Antigens, CD/immunology[MESH]|CD48 Antigen[MESH]|Cytokines/metabolism[MESH]|Cytoplasm[MESH]|Down-Regulation[MESH]|Histocompatibility Antigens Class I/immunology[MESH]|Humans[MESH]|Killer Cells, Natural/*immunology[MESH]|Leukocyte Immunoglobulin-like Receptor B1[MESH]|Membrane Glycoproteins/immunology[MESH]|Receptors, IgG/immunology[MESH]|Receptors, Immunologic/*immunology[MESH]|Signaling Lymphocytic Activation Molecule Family[MESH] |
