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Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition Janin JStructure 1999[Dec]; 7 (12): R277-9Water molecules are found in abundance in protein-protein and protein-DNA interfaces. Although interface solvent molecules exchange quickly with the bulk solvent, structural and biochemical data suggest that water-mediated interactions are as important as direct hydrogen bonds in the stability and specificity of recognition.|DNA/*chemistry/metabolism[MESH]|Humans[MESH]|Hydrogen Bonding[MESH]|Models, Molecular[MESH]|Nucleic Acid Conformation[MESH]|Protein Conformation[MESH]|Proteins/*chemistry/metabolism[MESH]|Water[MESH] |
