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Survey and summary: transcription by RNA polymerases I and III Paule MR; White RJNucleic Acids Res 2000[Mar]; 28 (6): 1283-98The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA. Although pol II has received most attention, pol I and pol III are together responsible for the bulk of transcriptional activity. This survey will summarise what is known about the process of transcription by pol I and pol III, how it happens and the proteins involved. Attention will be drawn to the similarities between the three nuclear RNA polymerase systems and also to their differences.|Animals[MESH]|Chromatin/genetics[MESH]|Humans[MESH]|Promoter Regions, Genetic/genetics[MESH]|RNA Polymerase I/chemistry/*metabolism[MESH]|RNA Polymerase III/chemistry/*metabolism[MESH]|Transcription Factors/metabolism[MESH]|Transcription, Genetic/*genetics[MESH] |
