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Base excision repair of DNA in mammalian cells Krokan HE; Nilsen H; Skorpen F; Otterlei M; Slupphaug GFEBS Lett 2000[Jun]; 476 (1-2): 73-7Base excision repair (BER) of DNA corrects a number of spontaneous and environmentally induced genotoxic or miscoding base lesions in a process initiated by DNA glycosylases. An AP endonuclease cleaves at the 5' side of the abasic site and the repair process is subsequently completed via either short patch repair or long patch repair, which largely require different proteins. As one example, the UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) uracil DNA glycosylase and prevents accumulation of uracil in the genome. BER is likely to have a major role in preserving the integrity of DNA during evolution and may prevent cancer.|*Base Pair Mismatch[MESH]|*DNA Glycosylases[MESH]|*DNA Repair[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Biological Evolution[MESH]|DNA Damage[MESH]|Humans[MESH]|Mammals[MESH]|Molecular Sequence Data[MESH]|N-Glycosyl Hydrolases/chemistry/*metabolism[MESH]|Uracil-DNA Glycosidase[MESH] |
