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Actinic keratosis is squamous cell carcinoma Lober BA; Lober CWSouth Med J 2000[Jul]; 93 (7): 650-5BACKGROUND: The prevalence of nonmelanoma skin cancer in the United States is alarming. It can be most appropriately treated if the earliest manifestation of cutaneous squamous cell carcinoma is recognized. METHODS: Clinical, histologic, and molecular biology, considerations were reviewed to determine whether actinic keratosis is the earliest clinical manifestation of cutaneous squamous cell carcinoma. RESULTS: The clinical, histologic, and molecular parameters of actinic keratosis are those of squamous cell carcinoma. CONCLUSION: Actinic keratosis does not transform, convert, or progress into cutaneous squamous cell carcinoma but is the earliest clinically recognizable manifestation of this malignancy.|Carcinoma, Squamous Cell/genetics/*pathology[MESH]|Cell Transformation, Neoplastic/pathology[MESH]|Epidermis/pathology[MESH]|Humans[MESH]|Keratinocytes/pathology[MESH]|Keratosis/genetics/*pathology[MESH]|Molecular Biology[MESH]|Neoplasm Invasiveness[MESH]|Precancerous Conditions/pathology[MESH]|Prevalence[MESH]|Skin Neoplasms/genetics/*pathology[MESH]|Terminology as Topic[MESH] |
