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Mitochondrial permeability transition and oxidative stress Kowaltowski AJ; Castilho RF; Vercesi AEFEBS Lett 2001[Apr]; 495 (1-2): 12-5Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.|*Ion Channels[MESH]|Animals[MESH]|Antioxidants/metabolism/pharmacology[MESH]|Apoptosis[MESH]|Calcium/metabolism/pharmacology[MESH]|Humans[MESH]|Membrane Proteins/drug effects/*physiology[MESH]|Mitochondrial Membrane Transport Proteins[MESH]|Mitochondrial Permeability Transition Pore[MESH]|NAD/metabolism[MESH]|Necrosis[MESH]|Oxidation-Reduction/drug effects[MESH]|Oxidative Stress/drug effects/*physiology[MESH]|Phosphates/metabolism/pharmacology[MESH]|Reactive Oxygen Species/metabolism[MESH]|Sulfhydryl Compounds/antagonists & inhibitors/metabolism[MESH] |
