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Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells Schaefer G; Venkataraman C; Schindler UJ Immunol 2001[May]; 166 (10): 5859-63Th cell subsets, namely Th1 and Th2 cells, play an important role in mounting an immune response against invading pathogens. Several genes are selectively up-regulated during differentiation and effector phases of Th subsets. In this study, we report the identification of a novel cytokine-like molecule designated FISP (IL-4-induced secreted protein), which is selectively expressed and secreted by Th2 cells. Detectable levels of FISP are observed only 3 days after initiation of Th2 differentiation. Expression of FISP in developing Th cells requires at least two signals: TCR signaling involving protein kinase C activation and STAT6-dependent IL-4R signaling.|*Interleukins[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Carrier Proteins/chemistry[MESH]|Cell Differentiation/immunology[MESH]|Cell Line[MESH]|Clone Cells[MESH]|Cytokines/biosynthesis/chemistry/genetics/*metabolism[MESH]|Female[MESH]|Genes, Tumor Suppressor[MESH]|Growth Substances/chemistry[MESH]|Humans[MESH]|Interleukin-4/*physiology[MESH]|Lymphocyte Activation[MESH]|Mice[MESH]|Mice, Inbred AKR[MESH]|Mice, Inbred BALB C[MESH]|Mice, Knockout[MESH]|Molecular Sequence Data[MESH]|Protein Biosynthesis[MESH]|Proteins/genetics/*metabolism[MESH]|Rats[MESH]|Receptors, Antigen, T-Cell/physiology[MESH]|Spleen/cytology[MESH]|Th1 Cells/metabolism[MESH]|Th2 Cells/cytology/*metabolism[MESH]|Transcription, Genetic/immunology[MESH] |
