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Procalcitonin: how a hormone became a marker and mediator of sepsis Muller B; Becker KLSwiss Med Wkly 2001[Oct]; 131 (41-42): 595-602Calcitonin was discovered in the early 1960s [1], at which time it was assumed to be a single hormone with a yet-to-be-determined role in human physiology. Since then it has been found to be only one entity among a large array of related circulating peptides, at least one of which has a pivotal role in the host response to microbial infections [2, 3]. The aim of this review is to describe this metamorphosis of an endocrine hormone to a new class of hormokine mediators in infectious diseases.|Biomarkers/blood[MESH]|Calcitonin Gene-Related Peptide[MESH]|Calcitonin/*blood/physiology[MESH]|Humans[MESH]|Practice Guidelines as Topic[MESH]|Protein Precursors/*blood/physiology[MESH]|Sensitivity and Specificity[MESH]|Sepsis/*blood/diagnosis/physiopathology[MESH] |
