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Some hints concerning the shape of T-cell receptor structures Rubin B; Alibaud L; Huchenq-Champagne A; Arnaud J; Toribio ML; Constans JScand J Immunol 2002[Feb]; 55 (2): 111-8Several models are proposed for T-cell antigen receptor (TCR) assembly and structure. However, there is little experimental data favouring directly either one or the other(s). The minimal complex appears to be composed of a TCRalphabeta/CD3deltaepsilon,gammaepsilon/zeta2 structure but at the cell membrane, multimers of this minimal structure may be formed. Quantitative cytofluometry has suggested three CD3epsilon chains for two TCRbeta (or TCRdelta) chains/complex. Such data should be repeated with monoclonal antibodies (MoAb) against extracellular (EC) parts of CD3delta or CD3gamma chains. In the present review, we have compared the TCR/CD3 assembly of pre-TCR, TCRgammadelta and TCRalphabeta containing complexes, and analysed the reactivity of antibodies (Abs) against the EC part of CD3delta chains. Our data suggest an alternative assembly pathway and structure of TCR/CD3 complexes.|Animals[MESH]|Antibodies[MESH]|CD3 Complex/chemistry/metabolism[MESH]|Humans[MESH]|Macromolecular Substances[MESH]|Models, Immunological[MESH]|Models, Molecular[MESH]|Receptors, Antigen, T-Cell, alpha-beta/chemistry/metabolism[MESH]|Receptors, Antigen, T-Cell, gamma-delta/chemistry/metabolism[MESH]|Receptors, Antigen, T-Cell/*chemistry/metabolism[MESH] |
