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The gentle art of gene arrangement: the meaning of gene clusters Trowsdale JGenome Biol 2002[]; 3 (3): COMMENT2002Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an advantage to such an arrangement? Some insights may come from large clusters of genes, such as the major histocompatibility complex which includes many genes involved in immune defense.|Animals[MESH]|Gene Order/*genetics[MESH]|Genes, MHC Class I/genetics[MESH]|Genes, MHC Class II/genetics[MESH]|Genomics[MESH]|Humans[MESH]|Immunity/genetics[MESH]|Multigene Family/*genetics[MESH] |