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Review article: monitoring for drug side-effects in inflammatory bowel disease Cunliffe RN; Scott BBAliment Pharmacol Ther 2002[Apr]; 16 (4): 647-62The side-effects suitable for monitoring in patients with inflammatory bowel disease being treated with the four main groups of drugs (5-aminosalicylic acid preparations, azathioprine and 6-mercaptopurine, methotrexate, and corticosteroids) are reviewed. On the basis of the reported frequency, severity and timing of side-effects, a practical scheme of monitoring is recommended. This includes a baseline measurement of full blood count, creatinine and liver function tests in all patients. In the absence of worrying symptoms, we recommend the following: (i) no monitoring for sulfasalazine; (ii) for other 5-aminosalicylic acid preparations, the measurement of creatinine at 6 and 12 months and then annually; (iii) for azathioprine/6-mercaptopurine, thiopurine methyltransferase genotype/phenotype determination has no role in treatment monitoring, but a full blood count at 2 weeks, 1 month, 3 months and then every 3 months should be performed; (iv) for methotrexate, a full blood count and liver function tests should be performed every 3 months; (v) for steroids, dual energy X-ray absorptiometry bone scanning should be performed at the start of therapy, every year in which steroids are used if the T score is < 0, and every 3-5 years if the T score is > 0.|*Drug Monitoring[MESH]|Adrenal Cortex Hormones/adverse effects[MESH]|Aminosalicylic Acids/adverse effects[MESH]|Azathioprine/adverse effects[MESH]|Blood Cell Count[MESH]|Creatinine/analysis[MESH]|Inflammatory Bowel Diseases/*drug therapy[MESH]|Liver Function Tests[MESH]|Mercaptopurine/adverse effects[MESH]|Methotrexate/adverse effects[MESH] |