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lüll Genetic risk factors of chronic obstructive pulmonary disease Joos L; Pare PD; Sandford AJSwiss Med Wkly 2002[Jan]; 132 (3-4): 27-37Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only a minority of cigarette smokers develop symptomatic disease. Family and twin studies suggest that genetic factors also contribute to the development of COPD. We present a detailed literature review of the genes which have been investigated as potential risk factors for this disease.|*Genetic Predisposition to Disease[MESH]|Cystic Fibrosis Transmembrane Conductance Regulator/genetics[MESH]|Epoxide Hydrolases/genetics[MESH]|Genes[MESH]|Glutathione Transferase/genetics[MESH]|Heme Oxygenase (Decyclizing)/genetics[MESH]|Heme Oxygenase-1[MESH]|Humans[MESH]|Interleukin-1/genetics[MESH]|Membrane Proteins[MESH]|Pulmonary Disease, Chronic Obstructive/*genetics[MESH]|Receptors, Adrenergic, beta/genetics[MESH]|Risk Factors[MESH]|Tumor Necrosis Factor-alpha/genetics[MESH]|Vitamin D-Binding Protein/genetics[MESH]|alpha 1-Antitrypsin Deficiency/genetics[MESH] |