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Pathways of apoptosis in lymphocyte development, homeostasis, and disease Rathmell JC; Thompson CBCell 2002[Apr]; 109 Suppl (ä): S97-107Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.|*Apoptosis[MESH]|*Homeostasis[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Autoimmune Diseases/immunology/pathology[MESH]|Humans[MESH]|Immunologic Memory[MESH]|Lymphocytes/*cytology/immunology/metabolism/*pathology[MESH]|Mitochondria/metabolism[MESH]|Proto-Oncogene Proteins/metabolism[MESH] |
