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Apoptosome: the cellular engine for the activation of caspase-9 Shi YStructure 2002[Mar]; 10 (3): 285-8Characterization of the apoptosome by cryo-EM reveals a wheel-shaped heptameric assembly involving Apaf-1 and cytochrome c. This structure provides a framework for understanding the activation mechanisms of caspase-9, an important initiator caspase in apoptosis.|*Protein Structure, Tertiary[MESH]|Apoptosis/*physiology[MESH]|Apoptotic Protease-Activating Factor 1[MESH]|Caspase 9[MESH]|Caspases/*chemistry/*metabolism[MESH]|Cryoelectron Microscopy[MESH]|Cytochrome c Group/*chemistry[MESH]|Dimerization[MESH]|Enzyme Activation[MESH]|Models, Molecular[MESH]|Proteins/*chemistry[MESH] |
