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Transposable elements and the evolution of eukaryotic complexity Bowen NJ; Jordan IKCurr Issues Mol Biol 2002[Jul]; 4 (3): 65-76Eukaryotic transposable elements are ubiquitous and widespread mobile genetic entities. These elements often make up a substantial fraction of the host genomes in which they reside. For example, approximately 1/2 of the human genome was recently shown to consist of transposable element sequences. There is a growing body of evidence that demonstrates that transposable elements have been major players in genome evolution. A sample of this evidence is reviewed here with an emphasis on the role that transposable elements may have played in driving the evolution of eukaryotic complexity. A number of specific scenarios are presented that implicate transposable elements in the evolution of the complex molecular and cellular machinery that are characteristic of the eukaryotic domain of life.|*DNA Transposable Elements/genetics[MESH]|*Eukaryotic Cells/physiology[MESH]|*Evolution, Molecular[MESH]|Cell Nucleus/metabolism[MESH]|DNA, Intergenic[MESH]|Gene Expression Regulation[MESH]|Genome, Human[MESH]|Humans[MESH]|Immune System/physiology[MESH]|Neoplasms/genetics[MESH]|Reproduction[MESH] |
