Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12085234&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo Saeki T; Mhashilkar A; Swanson X; Zou-Yang XH; Sieger K; Kawabe S; Branch CD; Zumstein L; Meyn RE; Roth JA; Chada S; Ramesh ROncogene 2002[Jul]; 21 (29): 4558-66Overexpression of the melanoma differentiation associated gene-7 (mda-7) in vitro results in suppression of lung cancer cell proliferation. However, the ability of MDA-7 to suppress lung cancer in vivo has not been previously demonstrated. In this study, we investigated the possibility of inducing overexpression of the mda-7 gene in human non-small cell lung carcinoma cells in vivo and its effects on tumor growth. Adenovirus-mediated overexpression of MDA-7 in p53-wild-type A549 and p53-null H1299 subcutaneous tumors resulted in significant tumor growth inhibition through induction of apoptosis. In addition, decreased CD31/PECAM expression and upregulation of APO2/TRAIL were observed in tumors expressing MDA-7. In vivo studies correlated well with in vitro inhibition of lung tumor cell proliferation and endothelial cell differentiation mediated by Ad-mda7. These data demonstrate that Ad-mda7 functions as a multi-modality anti-cancer agent, possessing both, pro-apoptotic and anti-angiogenic properties. We demonstrate for the first time the potential therapeutic effects of Ad-mda7 in human lung cancer.|*Gene Expression Regulation, Neoplastic[MESH]|Adenoviridae/*genetics[MESH]|Animals[MESH]|Apoptosis[MESH]|Apoptosis Regulatory Proteins[MESH]|Cell Differentiation[MESH]|Cell Division[MESH]|Endothelium, Vascular/cytology/metabolism[MESH]|Genes, Tumor Suppressor[MESH]|Humans[MESH]|In Situ Nick-End Labeling[MESH]|Interleukins/*genetics/*metabolism[MESH]|Lung Neoplasms/*genetics/metabolism/*pathology[MESH]|Membrane Glycoproteins/metabolism[MESH]|Mice[MESH]|Neoplasm Transplantation[MESH]|Platelet Endothelial Cell Adhesion Molecule-1/metabolism[MESH]|Receptors, TNF-Related Apoptosis-Inducing Ligand[MESH]|Receptors, Tumor Necrosis Factor/metabolism[MESH]|TNF-Related Apoptosis-Inducing Ligand[MESH]|Time Factors[MESH]|Transplantation, Heterologous[MESH]|Tumor Cells, Cultured[MESH]|Tumor Necrosis Factor-alpha/metabolism[MESH] |