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Role of Akt signaling in vascular homeostasis and angiogenesis Shiojima I; Walsh KCirc Res 2002[Jun]; 90 (12): 1243-50Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase-dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.|*Neovascularization, Physiologic[MESH]|*Protein Serine-Threonine Kinases[MESH]|Animals[MESH]|Cell Division[MESH]|Cell Movement[MESH]|Cell Survival[MESH]|Endothelium, Vascular/*physiology[MESH]|Homeostasis[MESH]|Humans[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology[MESH]|Models, Biological[MESH]|Nitric Oxide Synthase Type III[MESH]|Nitric Oxide Synthase/metabolism[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Proto-Oncogene Proteins c-akt[MESH]|Proto-Oncogene Proteins/*physiology[MESH]|Signal Transduction[MESH] |
