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Use of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human disease Bill JR; Kotzin BLArthritis Res 2002[]; 4 (4): 261-5Most techniques that identify antigen-specific T cells are dependent on the response of these cells to the relevant antigen in culture. Soluble multimers of MHC molecules, when occupied with the same peptide, will bind selectively to T cells specific for that MHC/peptide complex. Techniques to produce fluorescent MHC class II/peptide multimers have recently been developed. These reagents provide a method to facilitate detection and isolation of antigen-specific CD4+ T cells and they represent a new research tool to study these cells in patients with immune-mediated diseases.|Animals[MESH]|Antigen Presentation[MESH]|CD4-Positive T-Lymphocytes/*immunology[MESH]|Dimerization[MESH]|Flow Cytometry[MESH]|Histocompatibility Antigens Class II/*immunology[MESH]|Humans[MESH]|Immune System Diseases/*immunology[MESH]|Peptides/immunology[MESH]|Receptors, Antigen, T-Cell/*immunology[MESH]|Sensitivity and Specificity[MESH] |
