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lüll Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock Thompson CL; Sancar AOncogene 2002[Dec]; 21 (58): 9043-56Blue light governs a number of cellular responses in bacteria, plants, and animals, including photoreactivation, plant development, and circadian photoentrainment. These activities are mediated by a family of highly conserved flavoproteins, the photolyase/cryptochrome family. Photolyase binds to UV photoproducts in DNA and repairs them in a process called photoreactivation in which blue light is used to initiate a cyclic electron transfer to break bonds and restore the integrity of DNA. Cryptochrome, which has a high degree of sequence identity to photolyase, works as the main circadian photoreceptor and as a component of the molecular clock in animals, including mammals, and regulates growth and development in plants.|*Drosophila Proteins[MESH]|*Eye Proteins[MESH]|*Photoreceptor Cells, Invertebrate[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Circadian Rhythm/*physiology[MESH]|Cryptochromes[MESH]|DNA Repair/*physiology[MESH]|Deoxyribodipyrimidine Photo-Lyase/chemistry/genetics/*metabolism[MESH]|Flavoproteins/genetics/*metabolism[MESH]|Mammals[MESH]|Molecular Sequence Data[MESH]|Photons[MESH]|Plant Proteins/chemistry/genetics/metabolism[MESH]|Protein Conformation[MESH]|Pyrimidine Dimers/metabolism[MESH]|Receptors, G-Protein-Coupled[MESH]|Sequence Homology, Amino Acid[MESH] |