Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Calcineurin phosphatase activity and immunosuppression A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus Jorgensen KA; Koefoed-Nielsen PB; Karamperis NScand J Immunol 2003[Feb]; 57 (2): 93-8The mode of immunosuppressive action of tacrolimus (FK506) and cyclosporin A has been elucidated. Both drugs bind to proteins in the cytoplasm to form complexes, which in turn inhibit the phosphatase activity of calcineurin, an important limiting step in the activation of T cells. The association between drug uptake (pharmacokinetics) and enzyme inhibition (pharmacodynamics) is under current investigation. Great variations in the correlation between blood drug levels and enzyme inhibition could indicate that monitoring calcineurin phosphatase activity for treatment might be superior to monitoring blood drug levels.|Amino Acid Sequence[MESH]|Cyclosporine/*pharmacology[MESH]|Humans[MESH]|Immunosuppressive Agents/*pharmacology[MESH]|Molecular Sequence Data[MESH]|Phosphoric Monoester Hydrolases/antagonists & inhibitors/*immunology/metabolism[MESH]|Tacrolimus/*pharmacology[MESH]|Transplantation Immunology/immunology[MESH] |