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Unravelling the activation mechanisms of protein kinase B/Akt Scheid MP; Woodgett JRFEBS Lett 2003[Jul]; 546 (1): 108-12Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions.|*Protein Serine-Threonine Kinases[MESH]|Animals[MESH]|Cell Survival[MESH]|Enzyme Activation[MESH]|Gene Expression Regulation, Enzymologic[MESH]|Humans[MESH]|Isoenzymes/chemistry/genetics/metabolism[MESH]|Models, Biological[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Phosphorylation[MESH]|Protein Structure, Tertiary[MESH]|Proto-Oncogene Proteins c-akt[MESH]|Proto-Oncogene Proteins/chemistry/genetics/*metabolism[MESH]|Signal Transduction[MESH] |
