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Non-invasive techniques for the diagnosis of Helicobacter pylori infection Gatta L; Ricci C; Tampieri A; Vaira DClin Microbiol Infect 2003[Jun]; 9 (6): 489-96Helicobacter pylori infection can be diagnosed by invasive techniques requiring endoscopy and biopsy (histologic examination, culture, polymerase chain reaction), and non-invasive techniques (serology, urea breath test, urine or blood, detection of H. pylori antigen in stool specimen). However, recent studies have demonstrated that a strategy of 'testing and treating' for H. pylori in uninvestigated, young (<50 years), dyspeptic patients in primary care is safe and reduces the need for endoscopy. Indeed, a number of clinical guidelines recommend non-invasive testing in dyspeptic patients followed by treatment of H. pylori in primary care based on clinical and economic analyses. Several non-invasive tests are currently available on the market. The choice depends on the clinical circumstances, the likelihood ratio of positive and negative tests, the cost-effectiveness of the testing strategy, and, finally, the availability of the tests. Nevertheless, two non-invasive tests are commonly used: the urea breath test, and the stool antigen test.|*Bacterial Typing Techniques[MESH]|Helicobacter Infections/*diagnosis/immunology/urine[MESH]|Helicobacter pylori/immunology/*isolation & purification[MESH]|Humans[MESH] |
