Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Regulation of nitric oxide-sensitive guanylyl cyclase Friebe A; Koesling DCirc Res 2003[Jul]; 93 (2): 96-105In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the prosthetic heme group of the enzyme, two novel classes of GC activators have been identified that may have broad pharmacological implications. YC-1 and YC-1-like substances act as NO sensitizers, whereas the substance BAY 58-2667 stimulates NO-sensitive GC NO-independently and preferentially activates the heme-free form of the enzyme. Sensitization and desensitization of NO/cGMP signaling have been reported to occur on the level of NO-sensitive GC; in the present study, an alternative mechanism is introduced explaining the adaptation of the NO-induced cGMP response by a long-term activation of the cGMP-degrading phosphodiesterase 5 (PDE5). Finally, regulation of GC expression and a possible modulation of GC activity by other factors are discussed.|3',5'-Cyclic-GMP Phosphodiesterases/metabolism[MESH]|Animals[MESH]|Calcium/metabolism[MESH]|Cyclic GMP/metabolism[MESH]|Cyclic Nucleotide Phosphodiesterases, Type 5[MESH]|Enzyme Activation/drug effects/physiology[MESH]|Enzyme Activators/pharmacology[MESH]|Guanylate Cyclase/drug effects/*metabolism[MESH]|Humans[MESH]|Isoenzymes/drug effects/metabolism[MESH]|Nitric Oxide Donors/pharmacology[MESH]|Nitric Oxide/*metabolism[MESH]|Receptors, Cytoplasmic and Nuclear/drug effects/*metabolism[MESH]|Signal Transduction/physiology[MESH]|Soluble Guanylyl Cyclase[MESH] |
