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Pharmacologic treatment of poststroke depression: a systematic review of the literature Van de Meent H; Geurts AC; Van Limbeek JTop Stroke Rehabil 2003[Spr]; 10 (1): 79-92CLINICAL QUESTION/OBJECTIVE: A systematic evaluation of the literature published from 1966 until December 2001 on pharmacologic interventions for poststroke depression (PSD). DESIGN: Articles were selected from a computer-based search and were independently reviewed by three evaluators using a standardized criteria including internal validity items as well as descriptive and quantitative items. RESULTS: Fifty studies were preliminarily reviewed and 10 randomized controlled trials (RCTs) were included for systematic analysis. CONCLUSION: Selective serotonin reuptake inhibitors (citalopram and fluoxetine) may be effective in the treatment of PSD. There is some evidence for a beneficial effect of the tricyclic antidepressant nortriptyline, however, the RCTs for this medication lack sufficient validity, and reports on side effects are contradictory.|Antidepressive Agents/*therapeutic use[MESH]|Depressive Disorder/*drug therapy/*etiology[MESH]|Humans[MESH]|Stroke/*complications[MESH] |
