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The continuum of GERD complications Fennerty MBCleve Clin J Med 2003[Nov]; 70 Suppl 5 (ä): S33-50Complications of chronic gastroesophageal reflux disease (GERD) run the gamut from erosive esophagitis to esophageal cancer, but all are linked to repeated exposure of the esophagus to caustic gastric and duodenal acid. Progression from one complication to another is not clearly established across the GERD continuum, although there is a clear progression from the serious complication of Barrett's esophagus to esophageal adenocarcinoma. This review examines the range of complications that can arise from chronic GERD, underscoring the need to view heartburn as a symptom of a potentially serious condition.|Adenocarcinoma/epidemiology/*etiology/pathology[MESH]|Adult[MESH]|Age Distribution[MESH]|Aged[MESH]|Barrett Esophagus/epidemiology/*etiology/pathology[MESH]|Biopsy, Needle[MESH]|Child[MESH]|Esophageal Neoplasms/epidemiology/*etiology/pathology[MESH]|Esophagitis, Peptic/epidemiology/*etiology/pathology[MESH]|Esophagogastric Junction/*pathology[MESH]|Esophagoscopy[MESH]|Female[MESH]|Gastroesophageal Reflux/*complications/diagnosis[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Incidence[MESH]|Middle Aged[MESH]|Monitoring, Physiologic[MESH]|Prognosis[MESH]|Risk Assessment[MESH]|Severity of Illness Index[MESH]|Sex Distribution[MESH] |
