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Primer on medical genomics Part XI: Visualizing human chromosomes Spurbeck JL; Adams SA; Stupca PJ; Dewald GWMayo Clin Proc 2004[Jan]; 79 (1): 58-75In the past century, various methods to visualize human chromosomes were discovered. Chromosome analyses provide an overall view of the human genome that cannot be achieved with any other approach. The methods to visualize chromosomes include various techniques to produce bands along chromosomes, specialized procedures for specific disorders, and fluorescent-labeled DNA for targeted loci. Cytogenetic methods guide the study of the relationship between chromosome structure and gene function. They also aid in mapping locations of genes and identifying chromosome anomalies associated with medical disorders. The clinical diagnosis, prognosis, and response to treatment can be established for many malignant diseases. Cytogenetic methods provide an important diagnostic tool for clinical practice.|*Chromosome Structures[MESH]|Chromosome Aberrations[MESH]|Chromosome Banding/trends[MESH]|Chromosome Fragile Sites[MESH]|Cytogenetics[MESH]|Humans[MESH]|In Situ Hybridization, Fluorescence[MESH]|Sister Chromatid Exchange[MESH]|Terminology as Topic[MESH] |
