Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Inducible cAMP early repressor (ICER) in the nervous system--a transcriptional regulator of neuronal plasticity and programmed cell death Mioduszewska B; Jaworski J; Kaczmarek LJ Neurochem 2003[Dec]; 87 (6): 1313-20The acronym ICER (inducible cAMP early repressor) refers to a group of four proteins produced from the CREM/ICER gene due to use of an internal promoter (P2) placed in an intron of the CREM (cAMP responsive element modulator) gene. The ICER proteins contain DNA binding/leucine zipper domains that make them endogenous inhibitors of transcription driven by CREB (cAMP responsive element binding protein) and its cognates, CREM and ATF-1 (activating transcription factor-1). ICER expression is inducible in the brain and in neuronal culture by a variety of stimuli. As a CREB antagonist, ICER appears to be of pivotal importance in neuronal plasticity and programmed cell death.|*Repressor Proteins[MESH]|Animals[MESH]|Apoptosis/*physiology[MESH]|Circadian Rhythm[MESH]|Cyclic AMP Response Element Modulator[MESH]|Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors/metabolism[MESH]|DNA-Binding Proteins/chemistry/genetics/*physiology[MESH]|Gene Expression[MESH]|Nervous System Physiological Phenomena[MESH]|Neuronal Plasticity/*physiology[MESH]|Transcription, Genetic/physiology[MESH] |
