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Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools Park JW; Chun YS; Kim MSJ Pharmacol Sci 2004[Mar]; 94 (3): 221-32Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclampsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.|Animals[MESH]|Down-Regulation/genetics/physiology[MESH]|Drug Therapy/methods/*trends[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1, alpha Subunit[MESH]|Hypoxia/*etiology[MESH]|Oxygen/metabolism[MESH]|Transcription Factors/*adverse effects/genetics/metabolism[MESH] |