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Gastrointestinal satiety signals III Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide Stanley S; Wynne K; Bloom SAm J Physiol Gastrointest Liver Physiol 2004[May]; 286 (5): G693-7Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavior. This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans.|*Signal Transduction[MESH]|Digestive System/*metabolism[MESH]|Glucagon-Like Peptide 1[MESH]|Glucagon-Like Peptides/*physiology[MESH]|Glucagon/*physiology[MESH]|Humans[MESH]|Oxyntomodulin[MESH]|Pancreatic Polypeptide/*physiology[MESH]|Peptide Fragments/*physiology[MESH]|Peptide YY/*physiology[MESH]|Protein Precursors/*physiology[MESH]|Satiety Response/*physiology[MESH] |