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Review article: new pharmacological agents for the treatment of gastro-oesophageal reflux disease Vakil NAliment Pharmacol Ther 2004[May]; 19 (10): 1041-9Proton pump inhibitors, which act at the terminal point of acid secretion--the H+, K+-ATPase--are currently the most effective pharmacological treatments available for reflux disease. Despite the efficacy of the proton pump inhibitors, there is still potential for clinical improvement in gastro-oesophageal reflux disease pharmacotherapy. Faster onset of complete acid inhibition and improved duration of efficacy are two potential areas for improvement A number of novel pharmaceutical agents are currently undergoing clinical evaluation for the treatment of gastro-oesophageal reflux disease. These include transient lower oesophageal sphincter relaxation-reducing agents, serotonergic agents/prokinetics, potassium-competitive acid blockers, mucosal protectants, histamine H3 agonists and anti-gastrin agents. One or more of these drug groups may represent the future medical therapy for gastro-oesophageal reflux disease, should they prove effective in the clinical setting. This review summarizes the state of the art with these agents.|Gastric Mucosa/drug effects[MESH]|Gastrins/antagonists & inhibitors[MESH]|Gastroesophageal Reflux/*drug therapy[MESH]|Gastrointestinal Agents/therapeutic use[MESH]|Histamine Agonists/therapeutic use[MESH]|Humans[MESH]|Proton Pump Inhibitors[MESH]|Serotonin Agents/therapeutic use[MESH]|Sodium-Potassium-Exchanging ATPase/analysis/antagonists & inhibitors[MESH] |
