Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Targeting B cells for the treatment of rheumatoid arthritis Oligino TJ; Dalrymple SAArthritis Res Ther 2003[]; 5 Suppl 4 (Suppl 4): S7-11The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated the importance of this cell type in the pathogenesis of the disease. Elucidation of the molecular basis of B cell development and activation has allowed the identification of a number of possible therapeutic targets that are appealing for drug development. This review discusses briefly a number of these molecules and the rationale for targeting them for the treatment of RA.|Agammaglobulinaemia Tyrosine Kinase[MESH]|Antibodies, Monoclonal, Murine-Derived[MESH]|Antibodies, Monoclonal/*therapeutic use[MESH]|Antigens, CD19[MESH]|Arthritis, Rheumatoid/*drug therapy/immunology[MESH]|Autoimmunity[MESH]|B-Cell Activating Factor[MESH]|B-Lymphocytes/*immunology[MESH]|Chemokines, CXC[MESH]|Humans[MESH]|Immunologic Factors/*therapeutic use[MESH]|Membrane Proteins[MESH]|Protein-Tyrosine Kinases[MESH]|Receptors, CXCR5[MESH]|Receptors, Chemokine[MESH]|Receptors, Cytokine[MESH]|Rituximab[MESH]|Tumor Necrosis Factor-alpha[MESH] |
