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Making tubes: step by step Rosario M; Birchmeier WDev Cell 2004[Jul]; 7 (1): 3-5Branched hollow tubes form the architectural basis of many mammalian organs. The growth factor HGF/SF and its receptor, the Met receptor tyrosine kinase, stimulate epithelial cells to undergo tubulogenesis in vitro. In this issue of Developmental Cell, O'Brien et al. (2004) look at temporal regulation and the role of two HGF/SF effectors, the ERK 1/2 MAP kinases and matrix metalloproteases, in this process.|*Proto-Oncogene Proteins[MESH]|*Receptors, Growth Factor[MESH]|Animals[MESH]|Epithelial Cells/cytology/*metabolism[MESH]|Hepatocyte Growth Factor/*metabolism[MESH]|Humans[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Mitogen-Activated Protein Kinases/metabolism[MESH]|Mitogens/*metabolism[MESH]|Organogenesis/*physiology[MESH]|Proteins/metabolism[MESH]|Proto-Oncogene Proteins c-met[MESH]|Viscera/cytology/*embryology/*metabolism[MESH] |
