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English Wikipedia
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The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity Schachter ADPediatr Transplant 2004[Aug]; 8 (4): 344-8Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune-mediated and structural/genetic factors.|Actinin/blood[MESH]|Child[MESH]|Genetic Heterogeneity[MESH]|Humans[MESH]|Interferon-gamma/blood[MESH]|Interleukin-12/blood[MESH]|Interleukin-13/blood[MESH]|Interleukin-15/blood[MESH]|Interleukin-18/blood[MESH]|Interleukin-2/blood[MESH]|Interleukin-4/blood[MESH]|Intracellular Signaling Peptides and Proteins[MESH]|Membrane Proteins/blood[MESH]|Microfilament Proteins/blood[MESH]|NF-kappa B/blood[MESH]|Nephrotic Syndrome/*blood/*genetics/pathology[MESH]|Proteins/analysis[MESH]|Transforming Growth Factor beta/blood[MESH]|Tumor Necrosis Factor-alpha/analysis[MESH] |
