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Surgery for aneurysms of the aortic root: a 30-year experience Zehr KJ; Orszulak TA; Mullany CJ; Matloobi A; Daly RC; Dearani JA; Sundt TM 3rd; Puga FJ; Danielson GK; Schaff HVCirculation 2004[Sep]; 110 (11): 1364-71BACKGROUND: This study evaluated long-term results of aortic root replacement and valve-preserving aortic root reconstruction for patients with aneurysms involving the aortic root. METHODS AND RESULTS: Two-hundred three patients aged 53+/-16 years (mean+/-SD; 153 male, 50 female) underwent elective or urgent aortic root surgery from 1971 to 2000 for an aortic root aneurysm: 149 patients underwent a composite valve conduit reconstruction, and 54 patients underwent valve-preserving aortic root reconstruction. Fifty patients had Marfan syndrome. In-hospital and 30-day mortality was 4.0% (8/203) overall: for a composite valve conduit procedure, the corresponding value was 4.0% (6/149) and for valve-preserving procedure, 3.7% (2/54) (P=NS). Morbidity included 3 strokes (1%), 10 perioperative myocardial infarctions (5%), and 8 reoperations for bleeding (4%). Actuarial survival at 5, 10, 15, and 20 years was 93% (95% confidence interval [CI] = 88% to 97%), 79% (95% CI = 71% to 87%), 67% (95% CI = 57% to 79%), and 52% (95% CI = 36% to 69%), respectively. Freedom from reoperation was 72% (95% CI = 54% to 86%) at 20 years. Complications with anticoagulation occurred in 29 patients; with valve thrombosis, in 2; and with hemorrhage, in 27 (4 life threatening and 23 minor). Freedom from thromboembolism was 91% (95% CI = 77% to 98%) at 20 years. Freedom from endocarditis was 99% (95% CI = 92% to 100%) at 20 years. Multivariate analysis revealed preoperative mitral valve regurgitation (+3 to 4) and older age to be significant predictors of late death (P< or =0.005), and Marfan syndrome, initial valve-preserving aortic root reconstruction, and need for a concomitant procedure at initial operation to be significant predictors of the need for reoperation (P< or =0.01). CONCLUSIONS: Aortic root replacement for aortic root aneurysms can be done with low morbidity and mortality. Composite valve conduit reconstruction resulted in a durable result. There were few serious complications related to the need for long-term anticoagulation or a prosthetic valve. Reoperation was most commonly required because of failure of the aortic valve when a valve-preserving aortic root reconstruction was performed or for other cardiac or aortic disease elsewhere.|Adult[MESH]|Aged[MESH]|Anticoagulants/adverse effects/therapeutic use[MESH]|Aorta/*surgery[MESH]|Aortic Aneurysm/etiology/*surgery[MESH]|Disease-Free Survival[MESH]|Endocarditis/epidemiology[MESH]|Female[MESH]|Hospital Mortality[MESH]|Humans[MESH]|Length of Stay/statistics & numerical data[MESH]|Life Tables[MESH]|Male[MESH]|Marfan Syndrome/complications[MESH]|Middle Aged[MESH]|Mitral Valve Insufficiency/complications[MESH]|Myocardial Infarction/epidemiology[MESH]|Postoperative Complications/epidemiology[MESH]|Postoperative Hemorrhage/epidemiology[MESH]|Proportional Hazards Models[MESH]|Reoperation[MESH]|Retrospective Studies[MESH]|Sinus of Valsalva/*surgery[MESH]|Stroke/epidemiology[MESH]|Survival Analysis[MESH]|Survival Rate[MESH]|Thromboembolism/epidemiology[MESH] |