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Forefront of Na+/Ca2+ exchanger studies: role of Na+/Ca2+ exchanger--lessons from knockout mice Komuro I; Ohtsuka MJ Pharmacol Sci 2004[Sep]; 96 (1): 23-6We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.|Animals[MESH]|Male[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Myocardium/metabolism/pathology[MESH]|Sodium-Calcium Exchanger/*genetics/metabolism/*physiology[MESH] |
