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PGC-1alpha: turbocharging mitochondria Houten SM; Auwerx JCell 2004[Oct]; 119 (1): 5-7PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.|Animals[MESH]|Brain/metabolism/physiopathology[MESH]|Cell Respiration/*genetics[MESH]|Disease Models, Animal[MESH]|Energy Metabolism/*genetics[MESH]|Humans[MESH]|Mice[MESH]|Mitochondria/genetics/*metabolism[MESH]|Muscle, Skeletal/metabolism/physiopathology[MESH]|Neurodegenerative Diseases/genetics/metabolism/physiopathology[MESH]|Organ Specificity[MESH]|Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[MESH]|Trans-Activators/*deficiency/genetics[MESH]|Transcription Factors[MESH] |
