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Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity Moss SJ; Martin CJ; Wilkinson BNat Prod Rep 2004[Oct]; 21 (5): 575-93Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of chain extension. This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one module being used for multiple chain extension events (stuttering).|*Models, Molecular[MESH]|*Polyketide Synthases/chemistry/classification/genetics[MESH]|Biological Evolution[MESH]|Macrolides/*metabolism[MESH] |
